Evidence map›Paper›PMID 34301786›Full record

ReviewCancer discovery2021

Targeting

Catherine B Meador, Lecia V Sequist, Zofia Piotrowska

Open access · bronzeAbstract readReview
In one paragraph

Review in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Current paradigm of EGFRMed (New York, N.Y.) · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Pharmacokinetics, mass balance, and metabolism of [Cancer chemotherapy and pharmacology · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Catherine B MeadorDepartment of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-5006-3569
Lecia V SequistDepartment of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts. lvsequist@partners.org.ORCID 0000-0002-8965-6991
Zofia PiotrowskaDepartment of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Massachusetts General Hospital · US

Funding

The Activation of ERBB3 Signaling as a Resistance Mechanism to Targeted TherapiesR01CA137008 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron N Hata, ZOFIA PIOTROWSKA · 2009 to 2026
$5.7M
Using patient-derived models to understand drug responses in SCLCU01CA220323 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DYSON, NICHOLAS J · 2018 to 2022
$3.1M
NCI NIH HHS R01 CA137008NCI NIH HHS U01 CA220323
6 · The paper itself

Abstract

Approximately 10% of

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungErbB ReceptorsExonsHumansLung NeoplasmsMutationPrecision MedicineProtein Kinase InhibitorsAntineoplastic AgentsErbB ReceptorsProtein Kinase Inhibitors

Identifiers

PMID34301786
PMCPMC8673432
OpenAlexW3185544520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.