Evidence map›Paper›PMID 34301785›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Somatostatin Receptor Imaging and Theranostics: Current Practice and Future Prospects.

Sonya Park, Ashwin Singh Parihar, Lisa Bodei, Thomas A Hope, Nadine Mallak, Corina Millo, Kalpna Prasad, Don Wilson, Katherine Zukotynski, Erik Mittra

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Everolimus Related Acute Steatohepatitis Detected onNuclear medicine and molecular imaging · 2026
    Article
  4. VIPoma Presenting With Obstructive Jaundice: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2026
    Article
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  15. The utility ofThyroid research · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sonya ParkDepartment of Nuclear Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
Ashwin Singh PariharDepartment of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Lisa BodeiMolecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Thomas A HopeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Nadine MallakDepartment of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon.
Corina MilloDepartment of Nuclear Medicine, RAD&IS, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Kalpna PrasadDepartment of Nuclear Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
Don WilsonBC Cancer, Vancouver, British Columbia, Canada.
Katherine ZukotynskiDepartments of Radiology and Medicine, McMaster University, Hamilton, Ontario, Canada.
Erik MittraDepartment of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon; mittra@ohsu.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

A new era of precision diagnostics and therapy for patients with neuroendocrine neoplasms began with the approval of somatostatin receptor (SSTR) radiopharmaceuticals for PET imaging followed by peptide receptor radionuclide therapy (PRRT). With the transition from SSTR-based γ-scintigraphy to PET, the higher sensitivity of the latter raised questions regarding the direct application of the planar scintigraphy-based Krenning score for PRRT eligibility. Also, to date, the role of SSTR PET in response assessment and predicting outcome remains under evaluation. In this comprehensive review article, we discuss the current role of SSTR PET in all aspects of neuroendocrine neoplasms, including its relation to conventional imaging, selection of patients for PRRT, and the current understanding of SSTR PET-based response assessment. We also provide a standardized reporting template for SSTR PET with a brief discussion.

Indexed as

Neuroendocrine TumorsPositron-Emission TomographyReceptors, SomatostatinHumansMolecular ImagingPrecision MedicineRadiopharmaceuticalsRadiopharmaceuticalsReceptors, Somatostatin68Ga-DOTANOC68Ga-DOTATATEneuroendocrine neoplasmspeptide receptor radionuclide therapysomatostatinSSTR

Identifiers

PMID34301785
PMCPMC9364764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.