Evidence map›Paper›PMID 34301766›Full record

ArticleGenes & development2021

Bin Xue, Chen-Hua Chuang, Haydn M Prosser, Cesar Seigi Fuziwara, Claudia Chan, Neil Sahasrabudhe, Maximilian Kühn, Yalei Wu, Jingqi Chen, Anne Biton and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Decoding the NRF2-NOTCH Crosstalk in Lung Cancer-An Update.Antioxidants (Basel, Switzerland) · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bin XueDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.ORCID 0000-0002-5472-1300
Chen-Hua ChuangDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Haydn M ProsserThe Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.
Cesar Seigi FuziwaraDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.ORCID 0000-0002-0567-5432
Claudia ChanDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.
Neil SahasrabudheDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.
Maximilian KühnDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.
Yalei WuThermo Fisher Scientific, South San Francisco, California 94080, USA.
Jingqi ChenDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.ORCID 0000-0002-2454-0058
Anne BitonDepartment of Statistics, University of California at Berkeley, Berkeley, California 94705, USA.
Caifu ChenThermo Fisher Scientific, South San Francisco, California 94080, USA.
John Erby WilkinsonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Michael T McManusDepartment of Microbiology and Immunology, University of California at San Francisco Diabetes Center, W.M. Keck Center for Noncoding RNAs, University of California at San Francisco, San Francisco, California 94143, USA.
Allan BradleyThe Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.
Monte M WinslowDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Bo SuCentral Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Lin HeDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94705, USA.

Funding

The Cancer Target Discovery and Development Network at UCSFU01CA217882 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANDYOPADHYAY, SOURAV, BIVONA, TREVER G · 2017 to 2021
$5.2M
miR-200 miRNAs repress tumor metastasis in lung adenocarcinomaR01CA139067 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2009 to 2021
$3.3M
Molecular Dissection of an Arntl2 induced pro-metastatic secretomeR01CA204620 · NCI · STANFORD UNIVERSITY · PI WINSLOW, MONTE MEIER · 2016 to 2020
$1.8M
Molecular Dissection of Lung Cancer Progression and MetastasisR01CA175336 · NCI · STANFORD UNIVERSITY · PI WINSLOW, MONTE MEIER · 2013 to 2017
$1.7M
Rapid Fluorescent Tagging of Endogenous Proteins in Mouse ModelsR21OD027053 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HE, LIN · 2019 to 2020
$393k
NCI NIH HHS R01 CA139067NCI NIH HHS R01 CA175336NCI NIH HHS R01 CA204620NCI NIH HHS U01 CA217882NIH HHS R21 OD027053
6 · The paper itself

Abstract

Lung adenocarcinoma, the most prevalent lung cancer subtype, is characterized by its high propensity to metastasize. Despite the importance of metastasis in lung cancer mortality, its underlying cellular and molecular mechanisms remain largely elusive. Here, we identified

Indexed as

Cancer-Associated FibroblastsLung NeoplasmsMicroRNAsAnimalsCell Line, TumorCell ProliferationFibroblastsGene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisMicroRNAsMIRN200 microRNA, humancancer-associated fibroblastsJag1Jag2lung cancermetastasismicroenvironmentmiR-141miR-200miR-200cmiRNA

Identifiers

PMID34301766
PMCPMC8336896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.