ArticleHospital pediatrics2021
Acute Kidney Injury Among Children Admitted With Viral Rhabdomyolysis.
Article in Hospital pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- CK/Albumin and K/Ca ratios as predictors of clinical severity and renal replacement therapy in pediatric crush syndrome.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Rhabdomyolysis in Children: A State-of-the-Art Review.Children (Basel, Switzerland) · 2025Review
- Case Report: Virus-induced rhabdomyolysis ranging from mild course to acute renal injury, hyperferritinemia and poor outcome: a case series of four pediatric patients.Frontiers in pediatrics · 2025Article
- Benign acute childhood myositis: a retrospective cohort study from a large tertiary care children's hospital.Frontiers in pediatrics · 2025Article
- Acute Kidney Injury in Rhabdomyolysis: A 5-Year Children's Hospital Network Study.Healthcare (Basel, Switzerland) · 2024Article
- Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundInfectious etiologies cause a large portion of pediatric rhabdomyolysis. Among pediatric patients with rhabdomyolysis, it is unknown who will develop acute kidney injury (AKI). We sought to test the hypothesis that a viral etiology would be associated with less AKI in children admitted with rhabdomyolysis than a nonviral etiology.
methodsIn this single-center retrospective cohort study, patients <21 years of age admitted with acute rhabdomyolysis from May 1, 2010, through December 31, 2018, were studied. The primary outcome was development of AKI, defined by using the Kidney Disease: Improving Global Outcomes guidelines. The primary predictor was identification of viral infection by laboratory testing or clinical diagnosis. Covariates included age, sex, race, insurance provider, presence of proteinuria and myoglobinuria, and initial creatinine kinase and serum urea nitrogen. Routine statistics and multivariable logistic modeling were performed via SAS 9.4 (SAS Institute, Inc, Cary, NC).
resultsIn total, 319 pediatric patients with rhabdomyolysis were studied. The median age was 13 years. Patients were predominately male (69.9%), non-Hispanic Black (55.2%), and publicly insured (45.1%). We found no difference in the rates of AKI in those with a viral diagnosis versus those without a viral diagnosis (30 of 77 [39.0%] vs 111 of 234 [47.4%];
conclusionsIn our study, viral rhabdomyolysis did not have lower rates of AKI compared with nonviral etiologies of AKI; therefore, providers should consider continued caution in these patients.
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