SynthesisBMJ global health2021
Multiplexed technologies for sexually transmitted infections: global evidence on patient-centered and clinical health outcomes.
Synthesis in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cost-Effectiveness of an Enhanced Patient Care Intervention for Improving Viral Suppression Among Kenyan Adults Living With HIV.Value in health regional issues · 2025Trial
- Real-world impact of multiplex PCR testing on antimicrobial management in patients evaluated for sexually transmitted infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Review
- Epidemiological analysis of sexually transmitted infections pathogens and related microorganisms in South Korea: coinfection patterns and pathogen correlations.BMC infectious diseases · 2026Article
- The Critical Importance of Clinical Use Case to Inform Point-of-Care Technology Development: A Case Study of HIV Nucleic Acid Assays in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- A Triplex PCR Assay for Simultaneous Detection of Non-viral STDs in Both Dry and Wet Swabs, Offering a Rapid and Cost-Effective Diagnostic Tool.The Yale journal of biology and medicine · 2025Article
- Feasibility and staff acceptability of implementing Xpert HIV-1 viral load point-of-care testing: a pilot study in San Francisco.BMC infectious diseases · 2025Article
- Advantages of Syndromic Diagnostics: Detection of the Pathogens Causing Urethritis/Cervicitis with the STI CNM Real-Time PCR Kit from Vitro S.A.Polish journal of microbiology · 2024Article
- Feasibility, Preference, and Impact of a Rapid Multiplexed Point-of-Care Digital Innovation (AideSmart!) to Expedite Screening of Sexually Transmitted Blood-Borne Infections in At-Risk Populations in Canada: Cross-Sectional Study.Journal of medical Internet research · 2024Article
- Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections.International journal of molecular sciences · 2024Review
- Understanding the factors affecting global political priority for controlling sexually transmitted infections: a qualitative policy analysis.BMJ global health · 2024Article
- Sexually transmitted infections and associated risk factors among the transgender population of Pakistan.BMC infectious diseases · 2023Article
- Diagnostic performance of two rapid tests for syphilis screening in people living with HIV in Cali, Colombia.PloS one · 2023Article
- Editorial: Addressing the sexually transmitted infections epidemic in the United States: a sociomedical perspective.Frontiers in public health · 2023Article
- World AIDS Day 2022: A bittersweet commemoration of the global HIV/AIDS response.The Indian journal of medical research · 2022Article
- Copan Walk Away Specimen Processor (WASP) Automated System for Pathogen Detection in Female Reproductive Tract Specimens.Frontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionConventional care packages around screening for sexually transmitted infections (STIs) entail multiple clinic visits and precipitate losses to follow-up. To prevent these losses, multiplexed technologies for STIs (immunochromatographic tests/devices/assays and molecular assays that can screen multiple pathogens or multiple strains of one STI) can yield same-day results in a single visit. Research evidence of patient-centred (preference, satisfaction) and clinical health outcomes (feasibility, case positivity, uptake, impact) has not been synthesised. We conducted a systematic review to fill this gap.
methodsFor the period 2009-2020, two independent reviewers searched PubMed and Embase, retrieved 4440 citations and abstracted data from 42 relevant studies.
resultsOf 42 studies, 10 (23.8%) evaluated multiplexed immunochromatographic and 32 (76.2%) molecular assays. Outcomes were reported as follows: preference (n=3), satisfaction (n=2), uptake (n=1), feasibility (n=2), case positivity (n=42) and impact (n=11). Screened populations included various at-risk groups. A majority (86.1%-92.4%) of participants preferred (60.2%-97.2%) multiplexed technologies (over conventional testing). Compared with conventional lab-based testing, test uptake improved by 99.4% (hepatitis C), 99.6% (
conclusionsCompared with conventional lab-based testing, rapid multiplexed technologies were preferred by testees and led to quicker turnaround times for many STIs yielding same-day results thereby allowing to initiate rapid linkages to care. They were further shown to be highly feasible and impactful for detection and treatment facilitation. Based on these promising results, multiplexed technologies offer potential to screen at-risk populations to reduce onward STI transmission worldwide.
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