ArticleGenome research2021
Temperature dependence of spontaneous mutation rates.
Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Divergent Thermal Reaction Norms of the Spontaneous Mutation Rate Among Populations of Chironomus riparius.Molecular ecology · 2026Article
- Developmental speed and chronological time exert opposing effects on the spontaneous mutation rate inEvolution letters · 2026Article
- Influence of geography, seasonality and experimental selection on Chironomus riparius recombination rates.BMC genomics · 2026Article
- Bacterial diet influences mutation rate in Pristionchus pacificus.G3 (Bethesda, Md.) · 2026Article
- Genomes of Wiebesia Fig Wasps Reveal the Adaptation and Codiversification in the Fig-Fig Wasp Mutualism.Genome biology and evolution · 2026Article
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- The cycle of infectious fever - how it affects bacterial infections.Frontiers in cellular and infection microbiology · 2026Review
- Suppressor analysis inFrontiers in microbiology · 2026Article
- High-quality genome assembly of Chironomus riparius and its population history in European populations.G3 (Bethesda, Md.) · 2025Article
- Dissecting Oxidative Stress and Organismic Response to a Temperature Gradient in the MidgeEcology and evolution · 2025Article
- The interplay of recombination landscape and a transposable element in European populations of Chironomus riparius.BMC genomics · 2025Article
- Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut.ACS synthetic biology · 2025Article
- Information dynamics and the emergence of high-order individuality in ecosystems.Communications biology · 2025Article
- Low Mutation Rate and Atypical Mutation Spectrum in Prasinoderma coloniale: Insights From an Early Diverging Green Lineage.Genome biology and evolution · 2025Article
- Temperature dependence of the mutation rate towards antibiotic resistance.JAC-antimicrobial resistance · 2024Article
- Exploring the Frozen Armory: Antiphage Defense Systems in Cold-Adapted Bacteria with a Focus on CRISPR-Cas Systems.Microorganisms · 2024Article
- Genomics for monitoring and understanding species responses to global climate change.Nature reviews. Genetics · 2024Review
- Human DNA Mutations and their Impact on Genetic Disorders.Recent patents on biotechnology · 2024Review
- Germline mutation rate is elevated in young and old parents inEvolution letters · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation is the source of genetic variation and the fundament of evolution. Temperature has long been suggested to have a direct impact on realized spontaneous mutation rates. If mutation rates vary in response to environmental conditions, such as the variation of the ambient temperature through space and time, they should no longer be described as species-specific constants. By combining mutation accumulation with whole-genome sequencing in a multicellular organism, we provide empirical support to reject the null hypothesis of a constant, temperature-independent mutation rate. Instead, mutation rates depended on temperature in a U-shaped manner with increasing rates toward both temperature extremes. This relation has important implications for mutation-dependent processes in molecular evolution, processes shaping the evolution of mutation rates, and even the evolution of biodiversity as such.
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