Evidence map›Paper›PMID 34301621›Full record

ArticleArchives of disease in childhood2022

COVID-19 in children with haematological malignancies.

Gerard Cathal Millen, Roland Arnold, Jean-Baptiste Cazier, Helen Curley, Richard Feltbower, Ashley Gamble, Adam Glaser, Richard G Grundy, Laura Kirton, Lennard Y W Lee and 6 more

Abstract readComparative Study
In one paragraph

Article in Archives of disease in childhood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.Journal of the Pediatric Infectious Diseases Society · 2024
    Pooled it
  4. Article
  5. Article
  6. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.medRxiv : the preprint server for health sciences · 2024
    Article
  7. SARS-CoV-2 Infection and COVID-19 in Children.Clinics in chest medicine · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gerard Cathal MillenCancer Research UK Clinical Trials Unit, University of Birmingham Institute of Cancer and Genomic Sciences, Birmingham, UK g.millen@nhs.net.ORCID 0000-0003-1446-3228
Roland ArnoldInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Jean-Baptiste CazierCentre for Computational Biology, University of Birmingham, Birmingham, UK.
Helen CurleyInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Richard FeltbowerLeeds Institute for Data Analytics (LIDA), University of Leeds School of Medicine, Leeds, West Yorkshire, UK.
Ashley GambleCCLG Executive, Children's Cancer and Leukaemia Group, Leicester, UK.
Adam GlaserLeeds Institute for Data Analytics (LIDA), University of Leeds School of Medicine, Leeds, West Yorkshire, UK.
Richard G GrundyCCLG Executive, Children's Cancer and Leukaemia Group, Leicester, UK.
Laura KirtonCancer Research UK Clinical Trials Unit, University of Birmingham Institute of Cancer and Genomic Sciences, Birmingham, UK.
Lennard Y W LeeInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Martin G McCabeDivision of Cancer Sciences, The University of Manchester, Manchester, UK.
Claire PallesInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Bob PhillipsCentre for Reviews and Dissemination, University of York Alcuin College, York, UK.ORCID 0000-0002-4938-9673
Charles A StillerNational Cancer Registration and Analysis Service, Public Health England, London, UK.
Csilla VarnaiInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0003-0048-9507
Pamela KearnsCancer Research UK Clinical Trials Unit, University of Birmingham Institute of Cancer and Genomic Sciences, Birmingham, UK.

Funding

Cancer Research UK 28028Cancer Research UK 30259Medical Research Council G0800472
6 · The paper itself

Abstract

backgroundChildren with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.

methodsWe compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.

resultsOnly 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.

interpretationChildren with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.

Indexed as

Severity of Illness IndexAdolescentChildChild, PreschoolCohort StudiesCOVID-19FemaleHematologic NeoplasmsHumansInfantMaleRisk AssessmentRisk FactorsSARS-CoV-2COVID-19data collectionepidemiology

Identifiers

PMID34301621
PMCPMC8785070

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.