Evidence map›Paper›PMID 34301269›Full record

ArticleAIDS research and therapy2021

Should the management of high grade cervical squamous intraepithelial lesion (HSIL) be different in HIV-positive women?

Christine Gilles, Maude Velghe-Lenelle, Yannick Manigart, Déborah Konopnicki, Serge Rozenberg

Open access · goldAbstract read
In one paragraph

Article in AIDS research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christine GillesDepartment of Obstetrics and Gynecology, Saint Pierre University Hospital Brussels, Université Libre de Bruxelles (ULB), Free University of Brussels (ULB-VUB), 322 Rue Haute, 1000, Brussels, Belgium. christine.gilles@stpierre-bru.be.ORCID 0000-0003-4738-5924
Maude Velghe-LenelleDepartment of Obstetrics and Gynecology, Saint Pierre University Hospital Brussels, Université Libre de Bruxelles (ULB), Free University of Brussels (ULB-VUB), 322 Rue Haute, 1000, Brussels, Belgium.
Yannick ManigartDepartment of Obstetrics and Gynecology, Saint Pierre University Hospital Brussels, Université Libre de Bruxelles (ULB), Free University of Brussels (ULB-VUB), 322 Rue Haute, 1000, Brussels, Belgium.
Déborah KonopnickiInfectious Disease Department, Saint-Pierre University Hospital Brussels, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Serge RozenbergDepartment of Obstetrics and Gynecology, Saint Pierre University Hospital Brussels, Université Libre de Bruxelles (ULB), Free University of Brussels (ULB-VUB), 322 Rue Haute, 1000, Brussels, Belgium.
Université Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study compares the management and outcome of high grade squamous intraepithelial lesions (HSIL) in HIV-positive and -negative women and identifies risk factors for treatment failure.

methodsThis retrospective, controlled study includes 146 HIV-positive women, matched for HSIL, age and year of diagnosis, with 146 HIV-negative women. Differences were analysed using parametric and non-parametric tests and Kaplan-Meier survival curves. A binary logistic regression was used to assess risk factors for treatment failure.

resultsPersistence of cervical disease was observed most frequently in HIV-positive women (42 versus 17%) (p  <  0.001) and the cone biopsy margins were more often invaded in HIV-positive-women than in HIV-negative ones. (37 versus 16%; p  <  0.05). HIV-positive women, with successful cervical treatment had better HIV disease control: with significantly longer periods of undetectable HIV viral loads (VL) (19 versus 5 months; p  <  0.001) and higher CD4 counts (491 versus 320 cells/mm

Indexed as

HIV InfectionsSquamous Intraepithelial LesionsUterine Cervical DysplasiaUterine Cervical NeoplasmsFemaleHumansPregnancyRetrospective StudiesCINHIVHSILTreatment failure

Identifiers

PMID34301269
PMCPMC8305874
OpenAlexW3183771384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.