Evidence map›Paper›PMID 34301111›Full record

ArticlePolymers2021

Biofabrication of Cell-Laden Gelatin Methacryloyl Hydrogels with Incorporation of Silanized Hydroxyapatite by Visible Light Projection.

Jimmy Jiun-Ming Su, Chih-Hsin Lin, Hsuan Chen, Shyh-Yuan Lee, Yuan-Min Lin

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jimmy Jiun-Ming SuInstitute of Oral Biology, School of Dentistry, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Chih-Hsin LinGraduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei 110, Taiwan.
Hsuan ChenDepartment of Dentistry, School of Dentistry, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-5771-5547
Shyh-Yuan LeeDepartment of Dentistry, School of Dentistry, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-9880-2372
Yuan-Min LinDepartment of Dentistry, School of Dentistry, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0001-8697-978X

Funding

Ministry of Science and Technology, Taiwan MOST 105-2218-E-010-002
6 · The paper itself

Abstract

Gelatin methacryloyl (GelMA) hydrogel is a photopolymerizable biomaterial widely used for three-dimensional (3D) cell culture due to its high biocompatibility. However, the drawback of GelMA hydrogel is its poor mechanical properties, which may compromise the feasibility of biofabrication techniques. In this study, a cell-laden GelMA composite hydrogel with a combination incorporating silanized hydroxyapatite (Si-HAp) and a simple and harmless visible light crosslinking system for this hydrogel were developed. The incorporation of Si-HAp into the GelMA hydrogel enhanced the mechanical properties of the composite hydrogel. Moreover, the composite hydrogel exhibited low cytotoxicity and promoted the osteogenic gene expression of embedded MG63 cells and Human bone marrow mesenchymal stem cells (hBMSCs). We also established a maskless lithographic method to fabricate a defined 3D structure under visible light by using a digital light processing projector, and the incorporation of Si-HAp increased the resolution of photolithographic hydrogels. The GelMA-Si-HAp composite hydrogel system can serve as an effective biomaterial in bone regeneration.

Indexed as

3D printingdigital light processing projectiongelatin methacrylatehydroxyapatitemesenchymal stem cellssilanization

Identifiers

PMID34301111
PMCPMC8309475

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.