ArticlePolymers2021
Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.International journal of nanomedicine · 2025Pooled it
- Combination therapy of negative pressure wound therapy and antibiotic-loaded bone cement for accelerating diabetic foot ulcer healing: A prospective randomised controlled trial.International wound journal · 2024Trial
- Elution, Porosity, and Mechanical Performance of Vancomycin-Loaded Polymethylmethacrylate (PMMA) Bone Cement.Annals of biomedical engineering · 2026Article
- Impact of surface structuring on antibiotic elution from bone cement in two-stage revision for periprosthetic joint infection.BMC musculoskeletal disorders · 2026Article
- Early Postoperative Inflammatory Responses Following Primary Total Hip Arthroplasty Using Different Antibiotic-Loaded Bone Cement Formulations: A Prospective Observational Cohort Study.Journal of clinical medicine · 2026Article
- Research progress and future prospects of antibacterial drug-loaded bone cement in the treatment of orthopedic infections.Journal of orthopaedic surgery and research · 2026Review
- Antimicrobial 3D printed implants for periprosthetic joint infections.Drug delivery and translational research · 2026Article
- The effect of pulsatile lavage on antibiotic elution from bone cements in two-stage revision for periprosthetic joint infection.Journal of orthopaedic surgery and research · 2025Article
- Sequential application of vacuum sealing drainage and antibiotic-loaded bone cement for the successful treatment of a diabetic ischemic foot ulcer: a case report.Frontiers in endocrinology · 2025Article
- Investigation of the effect of debridement combined with antibiotic-loaded bone cement on pain and psychological status in diabetic foot ulcer patients.Frontiers in medicine · 2025Article
- A review on the promising antibacterial agents in bone cement-From past to current insights.Journal of orthopaedic surgery and research · 2024Review
- Does the Addition of Low-Dose Antibiotics Compromise the Mechanical Properties of Polymethylmethacrylate (PMMA)?Polymers · 2024Article
- Enhancing orthopedic outcomes: A comparative analysis of gentamicin sulphate and nanosilver in bone cement.Heliyon · 2024Article
- Evaluation of Gentamicin Release of PMMA Cements Using Different Methods: HPLC, Elution and Inhibition Zone Testing.Antibiotics (Basel, Switzerland) · 2024Article
- Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/α-TCP Composites: An In Vitro Study.Materials (Basel, Switzerland) · 2023Article
- A simple method to improve the antibiotic elution profiles from polymethylmethacrylate bone cement spacers by using rapid absorbable sutures.BMC musculoskeletal disorders · 2022Article
- Prophylactic Antibiofilm Activity of Antibiotic-Loaded Bone Cements against Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2022Article
- 3D Printing of Temporary Prostheses for Controlled-Release of Drugs: Design, Physical Characterization and Preliminary Studies.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Morphological properties of bone cement mixed with antibiotics.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement with considerable morbidity and large economic burdens. Antibiotic-Loaded Bone Cement (ALBC) has been developed as a valuable tool for local administration and is becoming one of the most effective methods for the prevention and treatment of orthopedic infections. Controlling antibiotic release from ALBC is critical to achieve effective infection control, however, the antibiotic elution rates are generally low, and the mechanisms are poorly understood. Thus, the present study aims to investigate the effects of the basic acrylic bone cement components, including liquid/powder (monomer-to-polymer) ratios, radiopacifier, initiator, and doses of antibiotics on the porosity, antibiotic elution rates and mechanical properties of polymethylmethacrylate (PMMA) based ALBC. The obtained results from the in vitro studies suggested that a reduction in the liquid/powder ratio and an increase in the radiopacifier ratio and gentamicin doses led to increased porosity and release of antibiotic, while the initiator ratio exerted no effect on elution rates. In conclusion, we hope that by varying the composition of ALBC, we could considerably enhance the antibiotic elution rates by increasing porosity, while maintaining an adequate mechanical strength of the bone cements. This finding might provide insights into controlling antibiotic release from ALBC to achieve effective infection control after total joint replacement surgery.
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Registered trials
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