ReviewMaterials (Basel, Switzerland)2021
Calcium Silicate-Based Root Canal Sealers: A Narrative Review and Clinical Perspectives.
Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Influence of sealer type on treatment outcome of teeth with apical periodontitis: a systematic review.Brazilian dental journalPooled it
- A 4-year follow-up of root canal obturation using a calcium silicate-based sealer and a zinc oxide-eugenol sealer: A randomized clinical trial.International endodontic journal · 2025Trial
- Influence of continuous chelation on the push-out bond strength of epoxy resin and calcium silicate sealers in oval root canals.Clinical oral investigations · 2026Article
- Comparative Dentinal Tubule Penetration of Three Calcium Silicate-Based Sealers Under Conventional and Sonic-Activated Final Irrigation Protocols: An In Vitro Confocal Microscopy Study.Dentistry journal · 2026Article
- Rheological Properties of Nine Commercially Available Endodontic Sealers by Substrate and Temperature: A Comparative In Vitro Study.Journal of functional biomaterials · 2026Article
- Evaluation of the physicochemical properties and adhesive interface quality of BioRoot Flow and BioRoot RCS endodontic sealers: An in vitro study.Clinical oral investigations · 2026Article
- Review
- Micro-CT analysis of calcium silicate-based cements in simulated acidic and neutral environments: a comparative study.BMC oral health · 2026Article
- Mesoporous Bioactive Glass Nanoparticle-Reinforced Calcium Silicate Sealer for Reduced Microleakage and Enhanced Antibacterial Performance.Journal of functional biomaterials · 2026Article
- Effects of resveratrol-enriched endodontic sealants on pulp stem cell viability and collagen production.Acta odontologica latinoamericana : AOL · 2026Article
- Surface Modification of Gutta-Percha for the Use of Intact MTA as a Root Canal Sealer.Journal of functional biomaterials · 2026Article
- Physiochemical properties of premixed bioceramic-based root canal sealer reinforced with copper oxide nanoparticles.Journal of conservative dentistry and endodontics · 2026Article
- Microhardness and structural changes in calcium silicate-based sealers after short-term exposure to EDTA and organic acids: an in vitro study.BMC oral health · 2026Article
- Cryotherapy-Driven Modulation of Postoperative Pain in Single-Visit Endodontic Treatment Across Different Obturation Materials: A Retrospective Study.Journal of clinical medicine · 2026Article
- Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.Clinical oral investigations · 2026Article
- Long-term outcome of combined orthograde and surgical management of perforating internal root resorption using a bioceramic repair material: an eight-year CBCT-documented case report.BMC oral health · 2026Article
- Ex vivo comparative analysis of retrievability among four calcium silicate-based sealers for regaining apical patency.Restorative dentistry & endodontics · 2026Article
- Effect of dentine moisture conditions on interfacial adaptation of a calcium silicate-based sealer compared with an epoxy resin-based sealer: an SEM/EDX analysis.Biomaterial investigations in dentistry · 2026Article
- Voids and marginal gaps in oval-shaped root canals filled with calcium silicate-based sealers: Micro-CT study.Brazilian dental journal · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last two decades, calcium silicate-based materials have grown in popularity. As root canal sealers, these formulations have been extensively investigated and compared with conventional sealers, such as zinc oxide-eugenol and epoxy resin-based sealers, in in vitro studies that showed their promising properties, especially their biocompatibility, antimicrobial properties, and certain bioactivity. However, the consequence of their higher solubility is a matter of debate and still needs to be clarified, because it may affect their long-term sealing ability. Unlike conventional sealers, those sealers are hydraulic, and their setting is conditioned by the presence of humidity. Current evidence reveals that the properties of calcium silicate-based sealers vary depending on their formulation. To date, only a few short-term investigations addressed the clinical outcome of calcium silicate-based root canal sealers. Their use has been showed to be mainly based on practitioners' clinical habits rather than manufacturers' recommendations or available evidence. However, their particular behavior implies modifications of the clinical protocol used for conventional sealers. This narrative review aimed to discuss the properties of calcium silicate-based sealers and their clinical implications, and to propose rational indications for these sealers based on the current knowledge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.