Evidence map›Paper›PMID 34300412›Full record

ReviewSensors (Basel, Switzerland)2021

Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing.

Mohamed H Hassan, Cian Vyas, Bruce Grieve, Paulo Bartolo

Open access · goldAbstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
22.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it, 332 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. F-doped KMnRSC advances · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Reservoir Computing-Based Glucose Sensing With an Enzymatic Reaction Network.Angewandte Chemie (International ed. in English) · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. pH-dependent rGO/Cu-CuRSC advances · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohamed H HassanDepartment of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-0832-8559
Cian VyasDepartment of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0001-6030-1962
Bruce GrieveDepartment of Electrical & Electronic Engineering, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-5130-3592
Paulo BartoloDepartment of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0003-3683-726X
University of Manchester · GB

Funding

Engineering and Physical Sciences Research Council EP/R513131/1
6 · The paper itself

Abstract

The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabrication techniques to produce novel glucose sensors that have higher sensitivity and selectivity, lower cost, and are simpler to use. A major focus has been on the development of enzymatic electrochemical sensors, typically using glucose oxidase. However, non-enzymatic approaches using direct electrochemistry of glucose on noble metals are now a viable approach in glucose biosensor design. This review discusses the mechanisms of electrochemical glucose sensing with a focus on the different generations of enzymatic-based sensors, their recent advances, and provides an overview of the next generation of non-enzymatic sensors. Advancements in manufacturing techniques and materials are key in propelling the field of glucose sensing, however, significant limitations remain which are highlighted in this review and requires addressing to obtain a more stable, sensitive, selective, cost efficient, and real-time glucose sensor.

Indexed as

Biosensing TechniquesElectrochemical TechniquesElectrochemistryGlucoseGlucose OxidaseHumansMetalsGlucoseGlucose OxidaseMetalselectrochemical sensorenzymaticglucose oxidationglucose sensornon-enzymatic

Identifiers

PMID34300412
PMCPMC8309655
OpenAlexW3178439329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.