Evidence map›Paper›PMID 34300313›Full record

ArticleJournal of clinical medicine2021

Inconsistent Findings of Cardiac Troponin T and I in Clinical Routine Diagnostics: Factors of Influence.

Abass Eidizadeh, Laura Fraune, Andreas Leha, Rolf Wachter, Abdul R Asif, Lutz Binder

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Abass EidizadehInstitute for Clinical Chemistry/Interdisciplinary UMG Laboratory, University Medical Center Goettingen, 37075 Goettingen, Germany.
Laura FrauneInstitute for Clinical Chemistry/Interdisciplinary UMG Laboratory, University Medical Center Goettingen, 37075 Goettingen, Germany.
Andreas LehaDepartment of Medical Statistics, University Medical Center Goettingen, 37073 Goettingen, Germany.ORCID 0000-0002-8072-1988
Rolf WachterGerman Centre for Cardiovascular Research (DZHK), 37075 Göttingen, Germany.ORCID 0000-0003-2231-2200
Abdul R AsifInstitute for Clinical Chemistry/Interdisciplinary UMG Laboratory, University Medical Center Goettingen, 37075 Goettingen, Germany.
Lutz BinderInstitute for Clinical Chemistry/Interdisciplinary UMG Laboratory, University Medical Center Goettingen, 37075 Goettingen, Germany.
University Hospital Leipzig · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac troponins are crucial for the diagnosis of acute myocardial infarction. Despite known differences in their diagnostic implication, there are no recommendations for only one of the two troponins, cardiac troponin I (cTnI) and troponin T (cTnT) so far. In an everyday routine diagnostic, cTnT (Roche) as well as cTnI (Abbott) were measured in 5667 samples from 3264 patient cases. We investigated the number of identical or discrepant troponin findings. Regarding cTnI, we considered both, sex-dependent and unisex cutoffs. In particular, the number of cTnT positive and cTnI negative results was strikingly high in 14.0% of cTnT positive samples and increases to 23.8% by using sex-specific cTnI cutoffs. This group was considerably greater than the group of cTnI positive and cTnT negative results, also after elimination of patients with an eGFR < 60 mL/min/1.73 m

Indexed as

99th percentile upper reference limitcardiac biomarkercomparisoncutoffsdiscrepancygendermyocardial infarctionsex-specifictroponin Itroponin T

Identifiers

PMID34300313
PMCPMC8305654
OpenAlexW3184817314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.