Evidence map›Paper›PMID 34300226›Full record

ArticleJournal of clinical medicine2021

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC.

Robert N Hawthorne, Adriana Blazeski, Justin Lowenthal, Suraj Kannan, Roald Teuben, Deborah DiSilvestre, Justin Morrissette-McAlmon, Jeffrey E Saffitz, Kenneth R Boheler, Cynthia A James and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Robert N HawthorneDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-4454-5753
Adriana BlazeskiDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Justin LowenthalDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-5909-0520
Suraj KannanDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Roald TeubenDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Deborah DiSilvestreDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Justin Morrissette-McAlmonDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Jeffrey E SaffitzDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Kenneth R BohelerDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Cynthia A JamesDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-8040-4600
Stephen P ChelkoDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-1675-5945
Gordon TomaselliDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Leslie TungDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Johns Hopkins University · USAlbert Einstein College of Medicine · USBeth Israel Deaconess Medical Center · USFlorida State University · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Engineered Human Heart Slice for Testing Drug-Induced ArrhythmiaR01HL152249 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BOHELER, KENNETH RICHARD, KWON, CHULAN · 2020 to 2022
$2.0M
ARVD/C Dysfunction in Human Stem Cell-Derived Cardiac TissueR01HL120959 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TUNG, LESLIE · 2016 to 2019
$1.9M
Maryland Stem Cell Research Fund 2016-MSCRF-I-2735NHLBI NIH HHS R01 HL120959NHLBI NIH HHS R01 HL152249NIGMS NIH HHS T32 GM136577NIH HHS R01-HL120959NIH HHS R01-HL148348NIH HHS R01-HL152249NIH HHS R01-HL152249-S2
6 · The paper itself

Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive heart condition which causes fibro-fatty myocardial scarring, ventricular arrhythmias, and sudden cardiac death. Most cases of ARVC can be linked to pathogenic mutations in the cardiac desmosome, but the pathophysiology is not well understood, particularly in early phases when arrhythmias can develop prior to structural changes. Here, we created a novel human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) model of ARVC from a patient with a c.2358delA variant in desmoglein-2 (

Indexed as

arrhythmogenic cardiomyopathyarrhythmogenic right ventricular cardiomyopathyARVCdesmoglein-2induced pluripotent stem cellsNFκB signalingpatient-derived stem cells

Identifiers

PMID34300226
PMCPMC8306340
OpenAlexW3179791530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.