ArticleJournal of clinical medicine2021
Increased Mortality in Elderly Patients Admitted with Hyponatremia: A Prospective Cohort Study.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- On the optimal sodium correction rate in hyponatraemia and clinical outcome: a meta-analysis.Emergency medicine journal : EMJ · 2026Pooled it
- A Data-Driven Threshold for Extreme Hyponatremia in the Emergency Department and Its Association With 28-Day Mortality.The Kaohsiung journal of medical sciences · 2026Article
- Incident hyponatremia among skilled nursing facility residents: association with enteral feeding tube use and chronic comorbidities.BMC nephrology · 2026Article
- Article
- Social Impact and Economic Burden of Uncoded Hyponatremia in Elderly - A Cost-of-Illness Study.ClinicoEconomics and outcomes research : CEOR · 2026Article
- Association Between Hyponatremia and Mortality and Readmission in Multimorbid Older Adults-A Cohort Study.Journal of clinical medicine · 2025Article
- Frailty and Cognitive Decline in Hospitalized Elderly Patients: Associations with Clinical and Laboratory Parameters.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Prognosis of Cancer Patients with Severe Hyponatremia in the Emergency Department: A Retrospective Study from the National Cancer Center of China.Current oncology (Toronto, Ont.) · 2025Article
- Effectiveness of an Early Intervention in Mild Hyponatremia to Prevent Accidental Falls in Hospitalized Older Adults-A Crossover Ecological Clinical Trial.Healthcare (Basel, Switzerland) · 2025Article
- An enigma of hypothyroidism and hyponatremia coexistence: a nationwide population-based retrospective study.BMC public health · 2023Article
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Diagnostic Workup and Outcome in Patients with Profound Hyponatremia.Journal of clinical medicine · 2023Article
- Prevalence, Risk Factors, and Mortality of Patients Presenting with Moderate and Severe Hyponatremia in Emergency Departments.Emergency medicine international · 2023Article
- Prevalence of hyponatremia among medically hospitalized patients and associated outcomes: a retrospective cohort study.Annals of Saudi medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia is the most common electrolyte disorder, commonly affecting older hospitalized individuals; however, the literature is not clear regarding its effect on mortality. The aim of this 2-year observational prospective cohort study was to evaluate the mortality and re-admission rates, the clinical and laboratory characteristics and the causes of hyponatremia in patients older than 65 years admitted with a corrected serum sodium of 130 mEq/L or less in an internal medicine ward of a tertiary Greek university hospital. During the observation period, 138 patients (mean age 80.5 years, 36.2% male) fulfilled the inclusion criteria and were prospectively followed for 1 year after admission. Symptoms of hyponatremia were present in 59.4% of patients. Hypovolemia was the main sole cause of hyponatremia, but in about one third of patients, hyponatremia was multifactorial. Only a low proportion of patients (12.3%) fulfilled the criteria of the syndrome of inappropriate antidiuresis (SIAD) at admission according to the current guidelines. The re-admission rates at 3- and 12-months following discharge was 34.2% and 51.8%, respectively. Mortality during hospitalization was 17.4% and was higher compared to non-hyponatremic admitted older patients, while the total mortality at 1 year after admission was 28.3%, indicating that hyponatremia at admission is a marker of significant mortality during and after hospitalization in elderly patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.