SynthesisInternational journal of environmental research and public health2021
Economic Burden of Stroke Disease: A Systematic Review.
Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 13 syntheses or guidelines pooled it, 206 citations in OpenAlex.
- Endovascular Treatment for Acute Ischemic Stroke: A Methodological Systematic Review of Health Economic Decision Modeling Studies.PharmacoEconomics · 2026Pooled it
- Adverse Drug Reaction Costs and Study Quality in Africa: A Systematic Review of Cost-of-Illness Studies.PharmacoEconomics - open · 2026Pooled it
- Indirect Costs of Non-Communicable Diseases within the Top Ten Causes of Mortality Worldwide: A Systematic Literature Review.Iranian journal of medical sciences · 2026Pooled it
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- Repetitive transcranial magnetic stimulation for motor function in stroke: a systematic review and meta-analysis of randomized controlled studies.Systematic reviews · 2025Pooled it
- A Systematic Literature Review on the Burden of Disease for Patients With Moderate to Severe Acute Ischemic Stroke.Medicine · 2025Pooled it
- Shuxuening injection for treating acute ischemic stroke: a PRISMA-compliant systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2024Pooled it
- Association between ambient temperature and risk of stroke morbidity and mortality: A systematic review and meta-analysis.Brain and behavior · 2023Pooled it
- [Organization and costs of stroke care in outpatient settings: Systematic review].Atencion primaria · 2023Pooled it
- Stress hyperglycemia and risk of adverse outcomes in patients with acute ischemic stroke: a systematic review and dose-response meta-analysis of cohort studies.Frontiers in neurology · 2023Pooled it
- Pooled it
- Transcranial direct current stimulation for gait recovery following stroke: A systematic review of current literature and beyond.Frontiers in neurology · 2022Pooled it
- The economic burden of stroke: a systematic review of cost of illness studies.Journal of medicine and lifePooled it
- Effect of robot-assisted gait training combined with electroacupuncture on lower limb motor function and brain network characteristics in stroke: an EEG study.Journal of neuroengineering and rehabilitation · 2025Trial
- Cost-effectiveness of MLC601 in post-stroke functional recovery compared with placebo - the CHIMES & CHIMES-E studies.BMC health services research · 2024Trial
- GLP-1 receptor agonists in stroke prevention: a narrative review on emerging therapeutic frontiers.Annals of medicine · 2026Review
- Article
- The impact of heat and cold events on direct, indirect, and intangible healthcare costs: a systematic review.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Ischemic Stroke Burden in China and Other G20 Nations (1990-2021): A Comparative Analysis From the Global Burden of Disease Study 2021 and Trend Projections Through 2031.Health care science · 2026Article
- Lived Experiences of Returning to Participation After Mild Stroke: A Phenomenological Study in Spain.Health expectations : an international journal of public participation in health care and health policy · 2026Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, one of the main causes of non-communicable disease as a cause of death every year is stroke. The objective of this study was to analyze the burden in consequence of stroke. This research used a systematic review method. Furthermore, a search for articles was carried out in June-July 2020. Four databases were used to search articles from 2015 to 2020. Eligible studies were identified, analyzed, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The inclusion criteria were prospective cost studies, retrospective cost studies, database analysis, mathematical models, surveys, and COI studies that assess burden of stroke in primary and referral healthcare (hospital-based). The results showed that from four databases, 9270 articles were obtained, and 13 articles were qualified. A total of 9270 articles had the identified search keywords, but only 13 articles met the set criteria for inclusion. The criteria for inclusion were stroke patients, the economic burden of stroke disease based on cost of illness method, which is approximately equal to USD 1809.51-325,108.84 (direct costs 86.2%, and indirect costs 13.8%). Those that used the health expenditure method did not present the total cost; instead, only either direct or indirect cost of health expenditure were reported. For most hospital admissions due to stroke, LOS (length of stay) was the dominant cost. The high economic burden to manage stroke justifies the promotion and preventive efforts by the policymakers and motivates the practice of healthy lifestyles by the people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.