Evidence map›Paper›PMID 34299683›Full record

ReviewInternational journal of environmental research and public health2021

Advanced Glycation End Products: New Clinical and Molecular Perspectives.

Juan Salazar, Carla Navarro, Ángel Ortega, Manuel Nava, Daniela Morillo, Wheeler Torres, Marlon Hernández, Mayela Cabrera, Lissé Angarita, Rina Ortiz and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Combination therapy: an upcoming paradigm to improve kidney and cardiovascular outcomes in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 7 countries.

Juan SalazarEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0003-4211-528X
Carla NavarroEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0002-1321-9568
Ángel OrtegaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0002-7180-4765
Manuel NavaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0001-9769-1693
Daniela MorilloFaculty of Medicine, School of Medicine, University of Buenos Aires, Buenos Aires 1121, Argentina.
Wheeler TorresEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.
Marlon HernándezFaculty of Medicine, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0001-9902-7438
Mayela CabreraCity of Houston Health Department, Houston, TX 77054, USA.
Lissé AngaritaEscuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andrés Bello, Sede Concepción 4260000, Chile.ORCID 0000-0001-7860-5112
Rina OrtizFacultad de Medicina, Universidad Católica de Cuenca, Cuenca 010105, Ecuador.
Maricarmen ChacínFacultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Luis D'MarcoDepartment of Nephrology, Hospital Clinico Universitario de Valencia, INCLIVA, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0003-0148-891X
Valmore BermúdezFacultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.ORCID 0000-0003-1880-8887
Universidad del Zulia · VEUniversidad Simón Bolívar · COHouston Health and Human Services Department · USUniversidad Andrés Bello · CLUniversidad Católica de Cuenca · ECUniversidad de Buenos Aires · ARUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications.

Indexed as

Glycation End Products, AdvancedHyperglycemiaFluorescenceHumansSkinGlycation End Products, Advancedadvanced glycation end productschronic complicationsdiabetes mellitusskin fluorescence

Identifiers

PMID34299683
PMCPMC8306599
OpenAlexW3181391308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.