Evidence map›Paper›PMID 34299679›Full record

ArticleInternational journal of environmental research and public health2021

Assessment of Unstimulated Whole Salivary Tumor Necrosis Factor Alpha (TNF-α) and Cellular Micronuclei Levels in Snuff (Naswar) Users and Non-Users for Early Diagnosis of Oral Squamous Cell Carcinoma.

Waqar Muhammad, Muhammad M Khan, Shafaq Zafar, Montaser N Alqutub, Abdulrahman M AlMubarak, Sameer Mokeem, Zafar A Khan, Muhammad K Usman, Naseer Ahmed, Nada Aldahiyan and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Waqar MuhammadDepartment of Oral Pathology, Peshawar Medical College, Warsak Road, Peshawar 25160, Pakistan.
Muhammad M KhanDepartment of Oral Pathology, Peshawar Medical College, Warsak Road, Peshawar 25160, Pakistan.
Shafaq ZafarDepartment of Pharmacology, Peshawar Medical College, Warsak Road, Peshawar 25160, Pakistan.
Montaser N AlqutubDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.
Abdulrahman M AlMubarakDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.
Sameer MokeemDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.
Zafar A KhanDepartment of Oral & Maxillofacial Surgery, College of Dentistry, Jouf University, Sakaka 72311, Saudi Arabia.ORCID 0000-0001-8593-3659
Muhammad K UsmanDepartment of Oral Pathology, Peshawar Medical College, Warsak Road, Peshawar 25160, Pakistan.
Naseer AhmedDepartment of Prosthodontics, Altamash Institute of Dental Medicine, Karachi 75500, Pakistan.ORCID 0000-0002-0960-1123
Nada AldahiyanDepartment of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.
Fahim VohraDepartment of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.ORCID 0000-0002-6204-7985
Tariq AbduljabbarDepartment of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.ORCID 0000-0001-7266-5886
King Saud University · SAKhyber Medical College · PKJouf University · SAKarachi Medical and Dental College · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to investigate the unstimulated whole saliva (UWS) tumor necrosis factor alpha (TNF-α) and cellular micronuclei in snuff dippers (Naswar) compared to healthy control subjects. The case control study was conducted over 9 months at a tertiary care center. Sixty patients were divided into two groups: Snuff dippers (SD) (Naswar) and non-snuff dippers (NSD) (control subjects). The included self-reported SD used Snuff twice daily for more than 12 months. UWS was collected and salivary TNF-α assessment was performed using enzyme-linked immunosorbent assay (ELISA). For cellular micronuclei, buccal mucosa was brushed to obtain cells in Naswar users, fixed with a dibutylphthalate polystyrene xylene (DPX) mounting to view micronuclei. Means and standard deviations were compared using the t-test and outcomes were related using Pearson correlation, considering

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsTobacco, SmokelessAdultCase-Control StudiesEarly DiagnosisHumansMiddle AgedSquamous Cell Carcinoma of Head and NeckTumor Necrosis Factor-alphaTumor Necrosis Factor-alphamicronucleinaswaroral cancersmokeless tobaccosnuff dippersTNF-α

Identifiers

PMID34299679
PMCPMC8307060
OpenAlexW3182137339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.