SynthesisInternational journal of environmental research and public health2021
Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies.
Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Comparative analysis of bacterial abundance and diversity in tumour tissue of oral squamous cell carcinoma and non-tumour tissue: insights from a systematic review of 16S ribosomal RNA sequencing.BMC oral health · 2025Pooled it
- First Description of Oral Microbiota in Domestic Cats Affected by Oral Squamous Cell Carcinoma.Pathogens (Basel, Switzerland) · 2026Article
- Microbial dysbiosis and host-microbe interactions in proliferative verrucous leukoplakia: insights into carcinogenic potential.Archives of microbiology · 2025Review
- Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study.International dental journal · 2025Article
- Dysbiosis of Oral Microbiome: A Key Player in Oral Carcinogenesis? A Critical Review.Biomedicines · 2025Review
- Oral microbial signatures underlying recurrence via PI3K/AKT/mTOR pathway modulation in oral squamous cell carcinoma.Journal of oral microbiology · 2025Article
- Comparative analysis of oral microbiome in saliva samples of oral leukoplakia, proliferative leukoplakia and oral squamous cell carcinoma.Frontiers in oral health · 2025Article
- Biological biomarkers of oral cancer.Periodontology 2000 · 2024Review
- Is Short-Read 16S rRNA Sequencing of Oral Microbiome Sampling a Suitable Diagnostic Tool for Head and Neck Cancer?Pathogens (Basel, Switzerland) · 2024Article
- The Impact of Oral Microbiome Dysbiosis on the Aetiology, Pathogenesis, and Development of Oral Cancer.Cancers · 2024Review
- Cancer and the Microbiome of the Human Body.Nutrients · 2024Review
- Rodent models for oral microbiome research: considerations and challenges- a mini review.Frontiers in oral health · 2024Review
- Integration of host gene regulation and oral microbiome reveals the influences of smoking during the development of oral squamous cell carcinoma.Frontiers in oncology · 2024Article
- Effect of different forms of tobacco on the oral microbiome in healthy adults: a systematic review.Frontiers in oral health · 2024Review
- Review
- Relative and Quantitative Characterization of the Bovine Bacterial Ocular Surface Microbiome in the Context of Suspected Ocular Squamous Cell Carcinoma.Animals : an open access journal from MDPI · 2023Article
- Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis.Heliyon · 2023Review
- Tumour microbiota structure predicts hypopharyngeal carcinoma recurrence and metastasis.Journal of oral microbiology · 2023Article
- Impact of waterpipe smoking on the salivary microbiome.Frontiers in oral health · 2023Article
- Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome.Frontiers in microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past decade has witnessed a surge in epidemiological studies that have explored the relationship between the oral microbiome and oral cancer. Owing to the diversity of the published data, a comprehensive systematic overview of the currently available evidence is critical. This review summarises the current evidence on the metagenomic studies on the oral microbiome in oral cancer. A systematic search was conducted in Medline and Embase databases to identify original studies examining the differences in the oral microbiome of oral cancer cases and controls. A total of twenty-six studies were identified that reported differences in microbial abundance between oral squamous cell carcinoma (OSCC) and controls. Although almost all the studies identified microbial dysbiosis to be associated with oral cancer, the detailed qualitative analysis did not reveal the presence/abundance of any individual bacteria or a consortium to be consistently enriched in OSCC samples across the studies. Interestingly, few studies reported a surge of periodontopathogenic taxa, especially
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.