Evidence map›Paper›PMID 34299644›Full record

ArticleMolecules (Basel, Switzerland)2021

Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin towards In Vitro Cytotoxicity and Molecular Docking on DNA Sequence.

Natalia Miklášová, Peter Herich, Juan Carlos Dávila-Becerril, Joaquín Barroso-Flores, Eva Fischer-Fodor, Jindra Valentová, Janka Leskovská, Jozef Kožíšek, Peter Takáč, Ján Mojžiš

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Natalia MiklášováDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia.
Peter HerichDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia.
Juan Carlos Dávila-BecerrilInstituto de Química Universidad Nacional Autónoma de México Circuito Exterior s/n Ciudad Universitaria, 04510 Ciudad de México, Mexico.
Joaquín Barroso-FloresInstituto de Química Universidad Nacional Autónoma de México Circuito Exterior s/n Ciudad Universitaria, 04510 Ciudad de México, Mexico.ORCID 0000-0003-0554-7569
Eva Fischer-FodorTumor Biology Department, Institute of Oncology "Prof. Dr. Ion Chiricuță", 400015 Cluj-Napoca, Romania.ORCID 0000-0002-0898-0547
Jindra ValentováDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia.
Janka LeskovskáDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia.
Jozef KožíšekDepartment of Physical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 81237 Bratislava, Slovakia.ORCID 0000-0003-4834-6636
Peter TakáčDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 04011 Košice, Slovakia.
Ján MojžišDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 04011 Košice, Slovakia.ORCID 0000-0002-7974-4525
Comenius University Bratislava · SKSlovak University of Technology in Bratislava · SKUniversidad Autónoma del Estado de México · MXUniversity of Pavol Jozef Šafárik · SKInstitute of Oncology Prof. Dr. Ion Chiricuta · RO

Funding

Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky APVV-19-0087 and VEGA Project No.1/0145/20Research and Development Operational Programme for the project "University Science Park of STU Bratislava" ITMS 26240220084
6 · The paper itself

Abstract

Metallodrugs form a large family of therapeutic agents against cancer, among which is cisplatin, a paradigmatic member. Therapeutic resistance and undesired side effects to Pt(II) related drugs, prompts research on different metal-ligand combinations with potentially enhanced biological activity. We present the synthesis and biological tests of novel palladium(II) complexes containing bisdemethoxycurcumin (BDMC)

Indexed as

Coordination ComplexesCytotoxinsDiarylheptanoidsDNA, NeoplasmMolecular Docking SimulationPalladium3T3 CellsAnimalsCaco-2 CellsCell ProliferationDrug Screening Assays, AntitumorHCT116 CellsHeLa CellsHumansJurkat CellsMCF-7 CellsbisdemethoxycurcuminCoordination ComplexesCytotoxinsDiarylheptanoidsDNA, NeoplasmPalladiumcytotoxicityDFT calculationsDNA-bindingHSA bindingpalladium(II) complexessynthetic bisdemethoxycurcumintranscription factor NF-κB

Identifiers

PMID34299644
PMCPMC8306502
OpenAlexW3183760990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.