Evidence map›Paper›PMID 34299628›Full record

ArticleMolecules (Basel, Switzerland)2021

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.

Olivier E Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E Dixon-Clarke, Alex N Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 4 countries.

Olivier E NongaInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.ORCID 0000-0001-8995-6313
Darja LavoginaInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Erki EnkvistInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.ORCID 0000-0001-7375-3765
Katrin KestavInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Apirat ChaikuadInstitut für Pharmazeutische Chemie, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0003-1120-2209
Sarah E Dixon-ClarkeCentre for Medicines Discovery, Old Road Campus, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.
Alex N BullockCentre for Medicines Discovery, Old Road Campus, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.ORCID 0000-0001-6757-0436
Sergei KopanchukInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.ORCID 0000-0003-1756-9327
Taavi IvanInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Ramesh EkambaramInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Kaido VihtInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.
Stefan KnappInstitut für Pharmazeutische Chemie, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.ORCID 0000-0001-5995-6494
Asko UriInstitute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.ORCID 0000-0001-5436-2427
University of Tartu · EEGoethe University Frankfurt · DEUniversity of Oxford · GB

Funding

Eesti Teadusagentuur PRG454Eesti Teadusagentuur PSG230EU/EFPIA/OICR/McGill/KTH/Diamond SGC no. 1097737Frankfurt Cancer Institute (FCI)Genome Canada through Ontario Genomics Institute OGI-196German translational cancer network (DKTK)Innovative Medicines Initiative 2 Joint Undertaking EUbOPEN 875510Medical Research Council and the Nuffield Department of Medicine, University of Oxford NDM Prize StudentshipWellcome Trust 106169/ZZ14/Z
6 · The paper itself

Abstract

We performed an X-ray crystallographic study of complexes of protein kinase PIM-1 with three inhibitors comprising an adenosine mimetic moiety, a linker, and a peptide-mimetic (d-Arg)

Indexed as

Fluorescent DyesMolecular ImagingPeptidomimeticsProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1CarbocyaninesCell Line, TumorCrystallography, X-RayHumansCarbocyaninescyanine dye 5Fluorescent DyesPeptidomimeticsPIM1 protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1adenosine–arginine conjugatebisubstrate inhibitorscellular uptake and localizationco-crystal structurefluorescent probesPIM kinasesprotein X-ray crystallography

Identifiers

PMID34299628
PMCPMC8307404
OpenAlexW3185614488

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.