Evidence map›Paper›PMID 34299626›Full record

ArticleMolecules (Basel, Switzerland)2021

Expanding the Use of Dynamic Electrostatic Repulsion Reversed-Phase Chromatography: An Effective Elution Mode for Peptides Control and Analysis.

Giulia Mazzoccanti, Simone Manetto, Michele Bassan, Marco Macis, Antonia Iazzetti, Walter Cabri, Antonio Ricci, Francesco Gasparrini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giulia MazzoccantiDepartment of Drug Chemistry and Technology, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8655-524X
Simone ManettoDepartment of Drug Chemistry and Technology, "Sapienza" University of Rome, 00185 Rome, Italy.
Michele BassanFresenius Kabi iPSUM, Piazza Maestri del Lavoro 7, 20063 Cernusco sul Naviglio, Italy.
Marco MacisFresenius Kabi iPSUM, Piazza Maestri del Lavoro 7, 20063 Cernusco sul Naviglio, Italy.
Antonia IazzettiDepartment of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-7792-774X
Walter CabriDepartment of Chemistry, Alma Mater Studiorum-University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0001-7865-0474
Antonio RicciFresenius Kabi iPSUM, Piazza Maestri del Lavoro 7, 20063 Cernusco sul Naviglio, Italy.
Francesco GasparriniDepartment of Drug Chemistry and Technology, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4954-7635

Funding

Fresenius Kabi La Sapienza University of Rome and the Fresenius Kabi Agreement 2020
6 · The paper itself

Abstract

Bioactive peptides are increasingly used in clinical practice. Reversed-phase chromatography using formic or trifluoroacetic acid in the mobile phase is the most widely used technique for their analytical control. However, sometimes it does not prove sufficient to solve challenging chromatographic problems. In the search for alternative elution modes, the dynamic electrostatic repulsion reversed-phase was evaluated to separate eight probe peptides characterised by different molecular weights and isoelectric points. This technique, which involves TBAHSO

Indexed as

Chromatography, Reverse-PhasePeptidesStatic ElectricityPeptidesbasic analytesdynamic electrostatic repulsive reversed-phasehigh peak capacitypeptide pharmaceuticals

Identifiers

PMID34299626
PMCPMC8303375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.