Evidence map›Paper›PMID 34299607›Full record

ArticleMolecules (Basel, Switzerland)2021

Reaction of Chalcones with Cellular Thiols. The Effect of the 4-Substitution of Chalcones and Protonation State of the Thiols on the Addition Process. Diastereoselective Thiol Addition.

Fatemeh Kenari, Szilárd Molnár, Pál Perjési

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. (International journal of molecular sciences · 2025
    Article
  5. Chalcones as Emerging Antibacterial Scaffolds: A Mini Review.Mini reviews in medicinal chemistry · 2025
    Review
  6. (Molecules (Basel, Switzerland) · 2024
    Article
  7. Article
  8. (International journal of molecular sciences · 2024
    Article
  9. Article
  10. (International journal of molecular sciences · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fatemeh KenariInstitute of Pharmaceutical Chemistry, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0002-5692-7775
Szilárd MolnárInstitute of Pharmaceutical Chemistry, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0002-4244-0069
Pál PerjésiInstitute of Pharmaceutical Chemistry, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0002-1057-9664
University of Pecs · HU

Funding

EFOP Operational Program (Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pécs) EFOP-3.6.1-16-2016-00004
6 · The paper itself

Abstract

Several biological effects of chalcones have been reported to be associated with their thiol reactivity. In vivo, the reactions can result in the formation of small-molecule or protein thiol adducts. Both types of reactions can play a role in the biological effects of this class of compounds. Progress of the reaction of 4-methyl- and 4-methoxychalcone with glutathione and

Indexed as

chalconecysteinediastereoselective additionglutathioneMichael additionthiols

Identifiers

PMID34299607
PMCPMC8308006
OpenAlexW3186851517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.