Evidence map›Paper›PMID 34299552›Full record

ReviewMolecules (Basel, Switzerland)2021

The Effects of Natural Products and Environmental Conditions on Antimicrobial Resistance.

Lulu Huang, Saeed Ahmed, Yufeng Gu, Junhong Huang, Boyu An, Cuirong Wu, Yujie Zhou, Guyue Cheng

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Antibacterial Activity of Rosmarinic Acid AgainstAnimals : an open access journal from MDPI · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Aerosolization AffectsMicroorganisms · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Potent Inhibition ofACS infectious diseases · 2024
    Article
  19. Article
  20. Restoring Ampicillin Sensitivity in Multidrug-ResistantJournal of microbiology and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lulu HuangMOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
Saeed AhmedDepartment of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Pakistan.
Yufeng GuMOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
Junhong HuangMOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
Boyu AnMOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
Cuirong WuMOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
Yujie ZhouCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Guyue ChengMOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.

Funding

the Fundamental Research Funds for the Central Universities Program No. 2020BC112the National Key R&D Program of China 2018YFD0500300the National Natural Science Foundation of China No. 32072921
6 · The paper itself

Abstract

Due to the extensive application of antibiotics in medical and farming practices, the continued diversification and development of antimicrobial resistance (AMR) has attracted serious public concern. With the emergence of AMR and the failure to treat bacterial infections, it has led to an increased interest in searching for novel antibacterial substances such as natural antimicrobial substances, including microbial volatile compounds (MVCs), plant-derived compounds, and antimicrobial peptides. However, increasing observations have revealed that AMR is associated not only with the use of antibacterial substances but also with tolerance to heavy metals existing in nature and being used in agriculture practice. Additionally, bacteria respond to environmental stresses, e.g., nutrients, oxidative stress, envelope stress, by employing various adaptive strategies that contribute to the development of AMR and the survival of bacteria. Therefore, we need to elucidate thoroughly the factors and conditions affecting AMR to take comprehensive measures to control the development of AMR.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaBacterial InfectionsBiological ProductsDrug Resistance, BacterialHumansAnti-Bacterial AgentsBiological Productsantimicrobial peptidesantimicrobial resistanceco-selectionheavy metalmicrobial volatile compoundsstress factors

Identifiers

PMID34299552
PMCPMC8303546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.