Evidence map›Paper›PMID 34299551›Full record

ArticleMolecules (Basel, Switzerland)2021

Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats.

Li Ping, Bingyong Xu, Qian Zhou, Yawen Hong, Qingmei Sun, Jincheng Wang, Difeng Zhu

Open access · goldAbstract readComparative Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Li PingCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Bingyong XuHangzhou Heze Pharmaceutical Technology Co., Ltd., Hangzhou 310018, China.
Qian ZhouDepartment of Pharmacy, Hangzhou Medical College, Hangzhou 310053, China.
Yawen HongCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Qingmei SunCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Jincheng WangCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Difeng ZhuCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-7257-5805
ZheJiang Institute For Food and Drug Control · CNHangzhou Medical College · CN

Funding

National Natural Science Foundation of China 81903708the National Key R&D Program of China 2016YFD0401103
6 · The paper itself

Abstract

Forchlorfenuron (CPPU) is a plant growth regulator extensively used in agriculture. However, studies on CPPU pharmacokinetics are lacking. We established and validated a rapid, sensitive, and accurate liquid chromatography-mass spectrometry method for CPPU detection in rat plasma. CPPU pharmacokinetics was evaluated in adult and juvenile rats orally treated with 10, 30, and 90 mg/kg of the compound. The area under the plasma drug concentration-time curve from 0 to 24 h (AUC), at the final time point sampled (AUC

Indexed as

Administration, OralAnimalsBiological AvailabilityChromatography, High Pressure LiquidFemaleMalePhenylurea CompoundsPlasmaPyridinesRatsRats, Sprague-DawleyTandem Mass SpectrometryN-(2-chloro-4-pyridyl)-N'-phenylureaPhenylurea CompoundsPyridinesforchlorfenuronjuvenile ratliquid chromatography-mass spectrometrypharmacokinetics

Identifiers

PMID34299551
PMCPMC8306460
OpenAlexW3178158358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.