Attachment of Single-Stranded DNA to Certain SERS-Active Gold and Silver Substrates: Selected Practical Tips.

Edyta Pyrak, Kacper Jędrzejewski, Aleksandra Szaniawska, Andrzej Kudelski

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

0.3field-weighted citation impact, top 53% of its field

1 · What the graph read from it

What it found

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0 citing papers in PubMed, 5 citations in OpenAlex.

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5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Edyta PyrakFaculty of Chemistry, University of Warsaw, 1 Pasteur St., 02-093 Warsaw, Poland.

Kacper JędrzejewskiFaculty of Chemistry, University of Warsaw, 1 Pasteur St., 02-093 Warsaw, Poland.

Aleksandra SzaniawskaFaculty of Chemistry, University of Warsaw, 1 Pasteur St., 02-093 Warsaw, Poland.

Andrzej KudelskiFaculty of Chemistry, University of Warsaw, 1 Pasteur St., 02-093 Warsaw, Poland.ORCID 0000-0003-1452-5951

University of Warsaw · PLInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PL

Funding

Narodowe Centrum Nauki 2019/35/B/ST4/02752

6 · The paper itself

Abstract

Layers formed from single-stranded DNA on nanostructured plasmonic metals can be applied as "working elements" in surface-enhanced Raman scattering (SERS) sensors used to sensitively and accurately identify specific DNA fragments in various biological samples (for example, in samples of blood). Therefore, the proper formation of the desired DNA layers on SERS substrates is of great practical importance, and many research groups are working to improve the process in forming such structures. In this work, we propose two modifications of a standard method used for depositing DNA with an attached linking thiol moiety on certain SERS-active structures; the modifications yield DNA layers that generate a stronger SERS signal. We propose: (i) freezing the sample when forming DNA layers on the nanoparticles, and (ii) when forming DNA layers on SERS-active macroscopic silver substrates, using

Indexed as

DNA, Single-StrandedGoldHexanolsMetal NanoparticlesSilverSpectrum Analysis, RamanSulfhydryl CompoundsSurface Properties6-mercapto-1-hexanolDNA, Single-StrandedGoldHexanolsSilverSulfhydryl CompoundsDNAgold nanoparticlesSERSsilver electrodessurface enhanced Raman spectroscopythiolated DNA

Identifiers

PMID34299520

DOI10.3390/molecules26144246

PMCPMC8305401

OpenAlexW3178324338

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.