Evidence map›Paper›PMID 34299492›Full record

ArticleMolecules (Basel, Switzerland)2021

Bufadienolides from the Skin Secretions of the Neotropical Toad

Candelario Rodriguez, Roberto Ibáñez, Luis Mojica, Michelle Ng, Carmenza Spadafora, Armando A Durant-Archibold, Marcelino Gutiérrez

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Pharmacological Effects of Cinobufagin.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Candelario RodriguezCentro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Apartado 0843-01103, Panama.ORCID 0000-0002-2156-4070
Roberto IbáñezSmithsonian Tropical Research Institute (STRI), Balboa, Ancon P.O. Box 0843-03092, Panama.ORCID 0000-0001-6118-5780
Luis MojicaCentro Nacional de Metrología de Panamá (CENAMEP AIP), Apartado 0843-01353, Panama.
Michelle NgCentro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, Apartado 0843-01103, Panama.
Carmenza SpadaforaCentro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, Apartado 0843-01103, Panama.ORCID 0000-0002-3002-9467
Armando A Durant-ArchiboldCentro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Apartado 0843-01103, Panama.ORCID 0000-0002-6516-9427
Marcelino GutiérrezCentro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Apartado 0843-01103, Panama.ORCID 0000-0003-1423-3772
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología · PAUniversidad de Panamá · PACentro Nacional de Metrología de Panamá (CENAMEP AIP)Smithsonian Tropical Research Institute · PA

Funding

INDICASAT IND-JAL-05Sistema Nacional de Investigación, Secretaría Nacional de Ciencia, Tecnología e Innovación SNI 163 2018
6 · The paper itself

Abstract

Toads in the family Bufonidae contain bufadienolides in their venom, which are characterized by their chemical diversity and high pharmacological potential. American trypanosomiasis is a neglected disease that affects an estimated 8 million people in tropical and subtropical countries. In this research, we investigated the chemical composition and antitrypanosomal activity of toad venom from

Indexed as

Amphibian VenomsAnimalsAntineoplastic AgentsAntiprotozoal AgentsBufanolidesBufonidaeCell Line, TumorChlorocebus aethiopsHumansMass SpectrometryMCF-7 CellsPanamaSkinTrypanosoma cruziVero CellsAmphibian VenomsAntineoplastic AgentsAntiprotozoal AgentsbufadienolideBufanolidesbufotalincinobufaginbufadienolidesRhinella alatatoadTrypanosoma cruzi

Identifiers

PMID34299492
PMCPMC8305532
OpenAlexW3181832990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.