Evidence map›Paper›PMID 34299491›Full record

ArticleMolecules (Basel, Switzerland)2021

Unlocking the Real Potential of Black Soldier Fly (

Ange Mouithys-Mickalad, Nuria Martin Tome, Thomas Boogaard, Arpita Chakraborty, Didier Serteyn, Kees Aarts, Aman Paul

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Gut Metabolome in Companion Animal Nutrition-Linking Diets to Health.Animals : an open access journal from MDPI · 2025
    Review
  2. Protein hydrolysates fromAnimal cells and systems · 2025
    Article
  3. Protein hydrolysates fromTranslational animal science · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ange Mouithys-MickaladCentre of Oxygen, Research and Development, University of Liege, 4000 Liege, Belgium.
Nuria Martin TomeProtix B.V., 5107 NC Dongen, The Netherlands.
Thomas BoogaardNutrilab B.V., 4283 GG Giessen, The Netherlands.
Arpita ChakrabortyProtix B.V., 5107 NC Dongen, The Netherlands.
Didier SerteynCentre of Oxygen, Research and Development, University of Liege, 4000 Liege, Belgium.
Kees AartsProtix B.V., 5107 NC Dongen, The Netherlands.
Aman PaulProtix B.V., 5107 NC Dongen, The Netherlands.ORCID 0000-0002-2720-8368
Protix (Netherlands) · NLUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Black soldier fly larvae (BSFL)-derived proteins are gaining popularity as sustainable pet food ingredients. According to the literature, these ingredients have strong antioxidant and antimicrobial activities. Due to the ability of BSFL protein derivatives to donate hydrogen atoms and/or electrons to counterpoise unstable molecules, they could possibly help in the prevention of osteoarthritis. During this study, the antiarthritic potential of BSFL protein derivatives was evaluated using the following assays: (1) proteinase inhibition, (2) erythrocyte membrane stability, (3) reactive oxygen species (ROS) production by activated macrophages, (4) ROS production by monocytes, and (5) cellular toxicity. Additionally, the glucosamine content of these ingredients was also evaluated. Chicken meal is commonly used in pet food formulations and was used as an industrial benchmark. The results obtained during this study demonstrated the strong antiarthritic potential of BSFL protein derivatives. We found that BSFL protein derivatives are not only useful in preventing the development of arthritis but could also help to cure it due to the presence of glucosamine. We also found that chicken meal could contribute to the development of arthritis by increasing ROS production by monocytes.

Indexed as

Animal FeedAnimalsCell Line, TumorChickensDietDipteraHL-60 CellsHumansLarvaProteinsProteinsarthritischicken mealerythrocytesglucosamineHermetia illucensmacrophagesmonocytespetsproteinase

Identifiers

PMID34299491
PMCPMC8304293
OpenAlexW3180970057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.