Evidence map›Paper›PMID 34299490›Full record

ArticleMolecules (Basel, Switzerland)2021

A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe.

Jenna M Len, Noor Hussein, Saloni Malla, Kyle Mcintosh, Rahul Patidar, Manivannan Elangovan, Karthikeyan Chandrabose, N S Hari Narayana Moorthy, Manoj Pandey, Dayanidhi Raman and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Evaluation of Chalcone (ACS omega · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jenna M LenDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Noor HusseinDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Saloni MallaDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Kyle McintoshDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.
Rahul PatidarSchool of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore 452001, India.
Manivannan ElangovanSchool of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore 452001, India.
Karthikeyan ChandraboseDepartment of Pharmacy, Indira Gandhi National Tribal University, Amarkantak 484887, India.
N S Hari Narayana MoorthyDepartment of Pharmacy, Indira Gandhi National Tribal University, Amarkantak 484887, India.
Manoj PandeyDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
Dayanidhi RamanDepartment of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-9340-1844
Piyush TrivediCenter of Innovation and Translational Research, Poona College of Pharmacy, Bhartiya Vidyapeeth, Pune 411038, India.
Amit K TiwariDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-7427-7155
University of Toledo · USDevi Ahilya Vishwavidyalaya · INIndira Gandhi National Tribal University · INCooper Medical School of Rowan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we designed, synthesized and evaluated, in vitro, novel chalcone analogs containing dialkylamino pharmacophores in the cervical cancer cell line, OV2008. The compound,

Indexed as

A549 CellsAnimalsApoptosisCell LineCell Line, TumorCell ProliferationChalconesCHO CellsCricetulusFemaleHEK293 CellsHeLa CellsHumansMembrane Potential, MitochondrialMitosisOxidative StressChalconescervical cancerchalconedialkylaminodrug discoveryintrinsic apoptosismitotic catastrophe

Identifiers

PMID34299490
PMCPMC8306139
OpenAlexW3182520638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.