Evidence map›Paper›PMID 34299479›Full record

ArticleMolecules (Basel, Switzerland)2021

Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids.

George E Magoulas, Pantelis Afroudakis, Kalliopi Georgikopoulou, Marina Roussaki, Chiara Borsari, Theano Fotopoulou, Nuno Santarem, Emile Barrias, Paloma Tejera Nevado, Julia Hachenberg and 12 more

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 6 countries.

George E MagoulasNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.ORCID 0000-0001-8944-1635
Pantelis AfroudakisNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.
Kalliopi GeorgikopoulouNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.
Marina RoussakiNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.
Chiara BorsariDepartment of Biomedicine, University of Basel, 4058 Basel, Switzerland.ORCID 0000-0002-4688-8362
Theano FotopoulouNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.
Nuno Santaremi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
Emile BarriasInstituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Paloma Tejera NevadoBernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
Julia HachenbergBernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
Eugenia BifeldBernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
Bernhard EllingerFraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525 Hamburg, Germany.ORCID 0000-0001-5703-3901
Maria KuzikovFraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525 Hamburg, Germany.ORCID 0000-0001-8771-1865
Irini FragiadakiDepartment of Clinical Microbiology and Microbial Pathogenesis, Faculty of Medicine, University of Crete, 70013 Heraklion, Greece.
Effie ScoulicaDepartment of Clinical Microbiology and Microbial Pathogenesis, Faculty of Medicine, University of Crete, 70013 Heraklion, Greece.
Joachim ClosBernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
Sheraz GulFraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525 Hamburg, Germany.ORCID 0000-0003-2543-1643
Maria Paola CostiDepartment of Pharmacy, Università degli Studi di Modena e Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-0443-5402
Wanderley de SouzaInstituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Kyriakos C ProusisNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.
Anabela Cordeiro da Silvai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0003-2392-6087
Theodora CalogeropoulouNational Hellenic Research Foundation, Institute of Chemical Biology, 11653 Athens, Greece.
National Hellenic Research Foundation · GRBernhard Nocht Institute for Tropical Medicine · DEFraunhofer Institute for Translational Medicine and Pharmacology · DEUniversidade Federal do Rio de Janeiro · BRUniversity of Crete · GRi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTUniversidade do Porto · PTUniversity of Basel · CHUniversity of Modena and Reggio Emilia · IT

Funding

Seventh Framework Programme 603240
6 · The paper itself

Abstract

A library of seventeen novel ether phospholipid analogues, containing 5-membered heterocyclic rings (1,2,3-triazolyl, isoxazolyl, 1,3,4-oxadiazolyl and 1,2,4-oxadiazolyl) in the lipid portion were designed and synthesized aiming to identify optimised miltefosine analogues. The compounds were evaluated for their in vitro antiparasitic activity against

Indexed as

Drug DesignAntiparasitic AgentsChagas DiseaseClick ChemistryHumansLeishmaniaLeishmaniasisMacrophagesPhospholipidsStructure-Activity RelationshipTrypanosoma cruziAntiparasitic AgentsPhospholipidsantiparasitic activityether phospholipidsheterocyclic ringsLeishmania donovaniLeishmania infantumTrypanosoma bruceiTrypanosoma cruzi

Identifiers

PMID34299479
PMCPMC8305768
OpenAlexW3179452408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.