Evidence map›Paper›PMID 34299459›Full record

ArticleMolecules (Basel, Switzerland)2021

Cytotoxicity of a Lipid-Rich Extract from Native Mexican Avocado Seed (

Salvador Padilla-Arellanes, Rafael Salgado-Garciglia, Marisol Báez-Magaña, Alejandra Ochoa-Zarzosa, Joel Edmundo López-Meza

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Salvador Padilla-ArellanesCentro Multidisciplinario de Estudios en Biotecnología-FMVZ, Universidad Michoacana de San Nicolás de Hidalgo, Posta Veterinaria, Morelia 58893, Mexico.
Rafael Salgado-GarcigliaInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mexico.ORCID 0000-0001-5920-6562
Marisol Báez-MagañaCentro Multidisciplinario de Estudios en Biotecnología-FMVZ, Universidad Michoacana de San Nicolás de Hidalgo, Posta Veterinaria, Morelia 58893, Mexico.
Alejandra Ochoa-ZarzosaCentro Multidisciplinario de Estudios en Biotecnología-FMVZ, Universidad Michoacana de San Nicolás de Hidalgo, Posta Veterinaria, Morelia 58893, Mexico.ORCID 0000-0003-3441-2989
Joel Edmundo López-MezaCentro Multidisciplinario de Estudios en Biotecnología-FMVZ, Universidad Michoacana de San Nicolás de Hidalgo, Posta Veterinaria, Morelia 58893, Mexico.ORCID 0000-0002-3269-9202
Universidad Michoacana de San Nicolás de Hidalgo · MX

Funding

Consejo Nacional de Ciencia y Tecnología CB 2016-287210Coordinación de la Investigación Científica 14.1, 2.10, and 14.5
6 · The paper itself

Abstract

Osteosarcoma is the most common malignant bone tumor in both children and dogs. It is an aggressive and metastatic cancer with a poor prognosis for long-term survival. The search for new anti-cancer drugs with fewer side effects has become an essential goal for cancer chemotherapy; in this sense, the bioactive compounds from avocado have proved their efficacy as cytotoxic molecules. The objective of this study was to determine the cytotoxic and antiproliferative effect of a lipid-rich extract (LEAS) from Mexican native avocado seed (

Indexed as

AnimalsApoptosisCell LineCytostatic AgentsDogsDrug SynergismLipidsMembrane Potential, MitochondrialMitochondriaOsteosarcomaPerseaPlant ExtractsSeedsCytostatic AgentsLipidsPlant ExtractsapoptosisavocadocanineosteosarcomaPersea americanasynergism

Identifiers

PMID34299459
PMCPMC8304388
OpenAlexW3178234136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.