Evidence map›Paper›PMID 34299423›Full record

ArticleMolecules (Basel, Switzerland)2021

Optimization of Multiparameters for Increased Yields of Cytochrome B5 in Bioreactors.

Ricardo F S Pereira, Carla C C R de Carvalho

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ricardo F S PereiraDepartment of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0001-9722-1931
Carla C C R de CarvalhoDepartment of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0002-8142-3835

Funding

Fundação para a Ciência e a Tecnologia "FCT Investigator 2013"Fundação para a Ciência e a Tecnologia IF/01203/2013/CP1163/CT0002Fundação para a Ciência e a Tecnologia UID/BIO/04565/2020
6 · The paper itself

Abstract

The production of recombinant proteins is gaining increasing importance as the market requests high quality proteins for several applications. However, several process parameters affect both the growth of cells and product yields. This study uses high throughput systems and statistical methods to assess the influence of fermentation conditions in lab-scale bioreactors. Using this methodology, it was possible to find the best conditions to produce cytochrome b5 with recombinant cells of

Indexed as

BiomassBioreactorsCulture MediaCytochromes b5Escherichia coliEscherichia coli ProteinsFermentationHigh-Throughput Screening AssaysModels, StatisticalRecombinant ProteinsCulture MediaCytochromes b5Escherichia coli ProteinsRecombinant Proteinsbioprocessbioreactorcytochrome b5fermentationpartial least squaresPID controllersrecombinant proteinscale up

Identifiers

PMID34299423
PMCPMC8306036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.