Evidence map›Paper›PMID 34299324›Full record

ArticleInternational journal of molecular sciences2021

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating.

Magdalena Antonowicz, Janusz Szewczenko, Joanna Jaworska, Katarzyna Jelonek, Kamil Joszko, Bożena Gzik-Zroska, Paweł M Nuckowski, Piotr Bryniarski, Zbigniew Paszenda, Damian S Nakonieczny and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recent development and future application of biodegradable ureteral stents.Frontiers in bioengineering and biotechnology · 2024
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Magdalena AntonowiczDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland.ORCID 0000-0001-5755-490X
Janusz SzewczenkoDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland.
Joanna JaworskaCentre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, Poland.
Katarzyna JelonekCentre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, Poland.ORCID 0000-0003-2625-5434
Kamil JoszkoDepartment of Biomechatronics, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland.ORCID 0000-0002-8229-3032
Bożena Gzik-ZroskaDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland.ORCID 0000-0003-4286-001X
Paweł M NuckowskiMaterials Research Laboratory, Faculty of Mechanical Engineering, Silesian University of Technology, 18A Konarskiego St., 44-100 Gliwice, Poland.ORCID 0000-0002-2606-0525
Piotr BryniarskiDepartment of Urology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 13-15 3 Maja St., 41-800 Zabrze, Poland.ORCID 0000-0002-7203-9006
Zbigniew PaszendaDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland.
Damian S NakoniecznyDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, Poland.
Karla Čech BarabaszováNanotechnology Centre, CEET, VŠB-Technical University of Ostrava, 17. Listopadu 15/2172, 708 00 Ostrava-Poruba, Czech Republic.ORCID 0000-0002-8667-4633
Janusz KasperczykCentre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, Poland.ORCID 0000-0002-8943-9508
Silesian University of Technology · PLCentre of Polymer and Carbon Materials · PLMedical University of Silesia · PLVSB - Technical University of Ostrava · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80-90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility.

Indexed as

Drug-Eluting StentsAbsorbable ImplantsBiocompatible MaterialsHumansPapaverinePolylactic Acid-Polyglycolic Acid CopolymerPolyurethanesUreteral ObstructionBiocompatible MaterialsPapaverinePolylactic Acid-Polyglycolic Acid CopolymerPolyurethanesbreak strengthdynamic frictional forcePLGA with papaverine hydrochloride coatingsradiopacityretention strengthureteral stent

Identifiers

PMID34299324
PMCPMC8307159
OpenAlexW3185284287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.