Evidence map›Paper›PMID 34299261›Full record

ReviewInternational journal of molecular sciences2021

Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues.

Lowell Dilworth, Aldeam Facey, Felix Omoruyi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 7 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 7 syntheses or guidelines pooled it, 337 citations in OpenAlex.

  1. Pooled it
  2. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.Cardiovascular & hematological disorders drug targets · 2026
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  7. The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review.International journal of molecular sciences · 2022
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lowell DilworthDepartment of Pathology, Mona Campus, University of the West Indies, Kingston 7, Jamaica.
Aldeam FaceyMona Academy of Sport, Mona Campus, University of the West Indies, Kingston 7, Jamaica.
Felix OmoruyiDepartment of Life Sciences, Texas A&M University, Corpus Christi, TX 78412, USA.ORCID 0000-0001-6926-8097
University of the West Indies System · JMTexas A&M University – Corpus Christi · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease.

Indexed as

AdipokinesAdiponectinAdipose TissueAdipose Tissue, BeigeAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsDiabetes ComplicationsDiabetes MellitusEnergy MetabolismHumansInsulinInsulin ResistanceLeptinObesityAdipokinesAdiponectinInsulinLeptinadiposediabetes mellitusinsulin resistance

Identifiers

PMID34299261
PMCPMC8305176
OpenAlexW3184056898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.