Evidence map›Paper›PMID 34299245›Full record

ArticleInternational journal of molecular sciences2021

Jiyeon Lee, Ji-Hyun Hwang, Harim Chun, Wonjin Woo, Sekyung Oh, Jungmin Choi, Lark Kyun Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jiyeon LeeSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
Ji-Hyun HwangInterdisciplinary Program of Integrated OMICS for Biomedical Science, The Graduate School, Yonsei University, Seoul 03722, Korea.ORCID 0000-0001-6009-0632
Harim ChunDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Wonjin WooSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
Sekyung OhDepartment of Medical Science, Catholic Kwandong University College of Medicine, Incheon 22711, Korea.ORCID 0000-0002-6880-5281
Jungmin ChoiDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Lark Kyun KimSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.ORCID 0000-0001-5983-4470
Yonsei University · KRKorea University · KRCatholic Kwandong University · KR

Funding

National Research Foundation of Korea NRF-2016M3C9A4921712National Research Foundation of Korea NRF-2016R1D1A1B01015292National Research Foundation of Korea NRF-2017M3A9G7073033National Research Foundation of Korea NRF-2019R1A4A1029000
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) records the second-lowest 5-year survival rate despite the avalanche of research into diagnosis and therapy. One of the major obstacles in treatment is chemoresistance to drugs such as 5-fluorouracil (5-FU), making identification and elucidation of chemoresistance regulators highly valuable. As the regulatory landscape grows to encompass non-coding genes such as long non-coding RNAs (lncRNAs), a relatively new class of lncRNA has emerged in the form of pseudogene-derived lncRNAs. Through bioinformatics analyses of the TCGA LIHC dataset, we have systematically identified pseudogenes of prognostic value. Initial experimental validation of selected pseudogene-derived lncRNA (

Indexed as

Adaptor Proteins, Signal TransducingBiomarkers, TumorCarcinoma, HepatocellularCell Line, TumorComputational BiologyDatabases, GeneticDisease ProgressionDrug Resistance, NeoplasmFluorouracilGene Expression ProfilingGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLiver NeoplasmsMicroRNAsPrognosisAdaptor Proteins, Signal TransducingBiomarkers, TumorFluorouracilMicroRNAsPLEKHA8 protein, humanRNA, Long Noncoding5-fluorouracilchemoresistancehepatocellular carcinomalong non-coding RNAPLEKHA8PLEKHA8P1pseudogene

Identifiers

PMID34299245
PMCPMC8304620
OpenAlexW3183701514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.