Evidence map›Paper›PMID 34299227›Full record

ArticleInternational journal of molecular sciences2021

Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of

Theresa A Engelmann, Lars Knudsen, Dominik H W Leitz, Julia Duerr, Michael F Beers, Marcus A Mall, Matthias Ochs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Longitudinal microcomputed tomography detects onset and progression of pulmonary fibrosis in conditionalAmerican journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Congenital Deletion ofInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Theresa A EngelmannInstitute for Forensic Medicine, Hannover Medical School, 30625 Hannover, Germany.
Lars KnudsenInstitute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-7926-3879
Dominik H W LeitzDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-0610-9088
Julia DuerrDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-4862-9487
Michael F BeersPulmonary, Allergy, and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Marcus A MallDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-4057-2199
Matthias OchsGerman Center for Lung Research (DZL), Associated Partner, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-0936-6979
Heidelberg University · DEMedizinische Hochschule Hannover · DEGerman Center for Lung Research · DEUniversity of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Alveolar Epithelial Cell Dysfunction in Pulmonary Fibrosis: Leveraging SFTPC Mutations for Discovery of Molecular and Cellular TargetsR01HL145408 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MICHAEL FRANCIS BEERS · 2019 to 2026
$4.6M
Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary FibrosisU01HL152970 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BEERS, MICHAEL FRANCIS · 2021 to 2024
$3.0M
Bundesministerium für Bildung, Wissenschaft und Forschung 82DZL004A1, 82DZL009B1Deutsche Forschungsgemeinschaft SFB 1449 B01, SFB-TR84 B08, SFB 1449 A01, C04 and Z02, 450557679NHLBI NIH HHS R01 HL145408NHLBI NIH HHS U01 HL152970NIEHS NIH HHS P30 ES013508U.S. Department of Veterans Affairs R01 HL145408, 2I01BX001176
6 · The paper itself

Abstract

Our previous study showed that in adult mice, conditional

Indexed as

Airway RemodelingAlveolar Epithelial CellsAnimalsEpithelial CellsFemaleFibrosisLungMaleMiceMice, KnockoutNedd4 Ubiquitin Protein LigasesPulmonary AlveoliPulmonary FibrosisPulmonary SurfactantsRespiratory MucosaNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesPulmonary Surfactantsalveolar epithelial type 2 cellsalveolar epitheliumNedd4-2pulmonary fibrosisregenerationstereologysurfactant

Identifiers

PMID34299227
PMCPMC8306112
OpenAlexW3186784131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.