Evidence map›Paper›PMID 34299209›Full record

ArticleInternational journal of molecular sciences2021

A Galantamine-Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells.

Kirilka Mladenova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Svetla Petrova, Jordan Doumanov, Irini Doytchinova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kirilka MladenovaFaculty of Biology, Sofia University, 1164 Sofia, Bulgaria.
Georgi StavrakovFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0002-8893-0346
Irena PhilipovaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-1192-1094
Mariyana AtanasovaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0001-9761-0355
Svetla PetrovaFaculty of Biology, Sofia University, 1164 Sofia, Bulgaria.
Jordan DoumanovFaculty of Biology, Sofia University, 1164 Sofia, Bulgaria.
Irini DoytchinovaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0002-1469-1768
Sofia University "St. Kliment Ohridski" · BGBulgarian Academy of Sciences · BGMedical University of Sofia · BG

Funding

Bulgarian National Roadmap for Research Infrastructure D01-271/2019Bulgarian National Science Fund DN03/9/2016Science and Education for Smart Growth Operational Program BG05M2OP001-1.001-0003
6 · The paper itself

Abstract

Misfolded amyloid beta (Aβ) peptides aggregate and form neurotoxic oligomers. Membrane and mitochondrial damages, calcium dysregulation, oxidative stress, and fibril deposits are among the possible mechanisms of Aβ cytotoxicity. Galantamine (GAL) prevents apoptosis induced by Aβ mainly through the ability to stimulate allosterically the α7 nAChRs and to regulate the calcium cytosolic concentration. Here, we examined the cytoprotective effects of two GAL derivatives, namely compounds

Indexed as

AcetylcholinesteraseAmyloid beta-PeptidesAntineoplastic AgentsAntioxidantsCholinesterase InhibitorsCurcuminCytoprotectionGalantamineHumansNeuroblastomaProtective AgentsTumor Cells, CulturedAcetylcholinesteraseAmyloid beta-PeptidesAntineoplastic AgentsAntioxidantsCholinesterase InhibitorsCurcuminGalantamineProtective Agentsamyloid beta peptidecurcumincytoprotectioncytotoxicitygalantaminegalantamine–curcumin hybridSH-SY5Y cell line

Identifiers

PMID34299209
PMCPMC8307467
OpenAlexW3180779227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.