Evidence map›Paper›PMID 34299206›Full record

ArticleInternational journal of molecular sciences2021

Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.

Zoltan Gombos, Erika Koltai, Ferenc Torma, Peter Bakonyi, Attila Kolonics, Dora Aczel, Tamas Ditroi, Peter Nagy, Takuji Kawamura, Zsolt Radak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Hormesis and Muscle Plasticity.Advances in experimental medicine and biology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. The Pathogenesis of Diabetes.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zoltan GombosResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.
Erika KoltaiResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.
Ferenc TormaResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.
Peter BakonyiResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.
Attila KolonicsResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.
Dora AczelResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.
Tamas DitroiDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, H-1122 Budapest, Hungary.
Peter NagyDepartment of Molecular Immunology and Toxicology, National Institute of Oncology, H-1122 Budapest, Hungary.ORCID 0000-0003-3393-235X
Takuji KawamuraFaculty of Sport Sciences, Waseda University, Tokorozawa 2-579-15, Japan.ORCID 0000-0003-2110-8718
Zsolt RadakResearch Center of Molecular Exercise Science, University of Physical Education, H-1123 Budapest, Hungary.ORCID 0000-0003-1297-6804
Hungarian University of Sports Science · HUNational Institute of Oncology · HUWaseda University · JP

Funding

Innovation and Technology Ministry, Hungary TKP2020-NKA-26
6 · The paper itself

Abstract

Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H

Indexed as

AnimalsCystathionine beta-SynthaseForkhead Box Protein O1HypertrophyMaleMuscle ProteinsMuscle, SkeletalNerve Tissue ProteinsNuclear ProteinsProto-Oncogene Proteins c-aktRatsRats, WistarRibosomal Protein S6 KinasesSestrinsSirtuin 1SirtuinsAkt1 protein, ratCystathionine beta-SynthaseForkhead Box Protein O1Foxo1 protein, ratmTOR protein, ratMuscle ProteinsNerve Tissue ProteinsNuclear ProteinsProto-Oncogene Proteins c-aktRibosomal Protein S6 KinasesSesn2 protein, ratSestrinsSirt1 protein, ratSIRT3 protein, ratSirtuin 1SirtuinsTOR Serine-Threonine Kinasesanabolic signaling pathwaysoverload-induced hypertrophyredox regulationskeletal muscle

Identifiers

PMID34299206
PMCPMC8305659
OpenAlexW3180480373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.