Evidence map›Paper›PMID 34299205›Full record

ArticleInternational journal of molecular sciences2021

Kaiso Regulates DNA Methylation Homeostasis.

Darya Kaplun, Alexey Starshin, Fedor Sharko, Kristina Gainova, Galina Filonova, Nadezhda Zhigalova, Alexander Mazur, Egor Prokhortchouk, Svetlana Zhenilo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 57 citations in OpenAlex.

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  11. The N-Terminal Part ofInternational journal of molecular sciences · 2023
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  12. The remodeling of Z-DNA in the mammalian germ line.Biochemical Society transactions · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Darya KaplunFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Alexey StarshinFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.ORCID 0000-0002-4965-0165
Fedor SharkoFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Kristina GainovaCentre for Strategic Planning of FMBA of Russia, 119071 Moscow, Russia.
Galina FilonovaFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Nadezhda ZhigalovaFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Alexander MazurFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Egor ProkhortchoukFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Svetlana ZheniloFederal State Institution «Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences», 119071 Moscow, Russia.
Russian Academy of Sciences · RUCenter for Strategic Research · RU

Funding

Russian Foundation for Basic Research 19-29-04139Russian Science Foundation 19-74-30026
6 · The paper itself

Abstract

Gain and loss of DNA methylation in cells is a dynamic process that tends to achieve an equilibrium. Many factors are involved in maintaining the balance between DNA methylation and demethylation. Previously, it was shown that methyl-DNA protein Kaiso may attract NCoR, SMRT repressive complexes affecting histone modifications. On the other hand, the deficiency of Kaiso resulted in reduced methylation of ICR in

Indexed as

DNA MethylationGenomic ImprintingLocus Control RegionDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BFibroblastsGene EditingHEK293 CellsHumansInsulin-Like Growth Factor IIPromoter Regions, GeneticRNA, Long NoncodingTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BH19 long non-coding RNAIGF2 protein, humanInsulin-Like Growth Factor IIRNA, Long NoncodingTranscription FactorsTRIM25 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesZBTB33 protein, humancancerde novo DNA methyltransferasesDNA methylationDNMT3a/3bKaiso

Identifiers

PMID34299205
PMCPMC8307659
OpenAlexW3185608775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.