Evidence map›Paper›PMID 34299200›Full record

ArticleInternational journal of molecular sciences2021

Somatotroph Tumors and the Epigenetic Status of the

Pauline Romanet, Justine Galluso, Peter Kamenicky, Mirella Hage, Marily Theodoropoulou, Catherine Roche, Thomas Graillon, Heather C Etchevers, Daniel De Murat, Grégory Mougel and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Clinical characteristics associated with somaticFrontiers in endocrinology · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. DNA Methylation in Pituitary Adenomas: A Scoping Review.International journal of molecular sciences · 2025
    Article
  6. Review
  7. Pituitary Tumorigenesis-Implications for Management.Medicina (Kaunas, Lithuania) · 2023
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Pauline RomanetAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, La Conception, Hospital Laboratory of Molecular Biology, 13385 Marseille, France.
Justine GallusoAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, La Conception, Hospital Laboratory of Molecular Biology, 13385 Marseille, France.
Peter KamenickyUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l'Hypophyse, 94270 Le Kremlin-Bicêtre, Île-de-France, France.
Mirella HageUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l'Hypophyse, 94270 Le Kremlin-Bicêtre, Île-de-France, France.
Marily TheodoropoulouMedizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig Maximilian University Munich, 80336 Munich, Germany.
Catherine RocheAPHM, La Conception Hospital, Laboratory of Molecular Biology, 13385 Marseille, France.
Thomas GraillonAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, La Timone Hospital Department of Neurosurgery, 13385 Marseille, France.
Heather C EtcheversAix Marseille Univ, INSERM, MMG, UMR1251, Marmara Institute, 13385 Marseille, France.ORCID 0000-0003-0201-3799
Daniel De MuratUniversité de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014 Paris, France.
Grégory MougelAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, La Conception, Hospital Laboratory of Molecular Biology, 13385 Marseille, France.
Dominique Figarella-BrangerAix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, 13385 Marseille, France.
Henry DufourAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, La Timone Hospital Department of Neurosurgery, 13385 Marseille, France.
Thomas CunyAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, Department of Endocrinology, Hospital La Conception, 13385 Marseille, France.
Guillaume AssiéUniversité de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014 Paris, France.
Anne BarlierAix Marseille Univ, INSERM, APHM, MMG, UMR1251, Marmara Institute, La Conception, Hospital Laboratory of Molecular Biology, 13385 Marseille, France.ORCID 0000-0002-3740-6173
Inserm · FRCentre National de la Recherche Scientifique · FRHôpital de la Conception · FRLMU Klinikum · DE

Funding

Excellence Initiative of Aix Marseille University -A*Midex- a French "Investissement d'Avenir" NAFrench Ministry of Health NAGroupement de Recherche CREST-NET GDR2031Institut National de lutte contre le Cancer (INCa) NAMarMaRa Institute NA
6 · The paper itself

Abstract

Forty percent of somatotroph tumors harbor recurrent activating

Indexed as

AdultAgedAged, 80 and overAllelesChromograninsDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticGenomic ImprintingGTP-Binding Protein alpha Subunits, GsHumansMaleMiddle AgedMutationPituitary NeoplasmsChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsepigeneticGNASgsp oncogeneimprintingPitNETpituitaryrelaxationsomatotrophtumorigenesis

Identifiers

PMID34299200
PMCPMC8306130
OpenAlexW3183834727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.