Evidence map›Paper›PMID 34299159›Full record

ArticleInternational journal of molecular sciences2021

Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod,

Gioele Capillo, Eugenia R Lauriano, Jose M Icardo, Prabhugouda Siriyappagouder, Michal Kuciel, Stelios Karapanagiotis, Giacomo Zaccone, Jorge M O Fernandes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Gioele CapilloDepartment of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168 Messina, Italy.ORCID 0000-0002-2002-1138
Eugenia R LaurianoDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Jose M IcardoDepartment of Anatomy and Cell Biology, Poligono de Cazona, Faculty of Medicine, University of Cantabria, 39011 Santander, Spain.ORCID 0000-0001-9543-2444
Prabhugouda SiriyappagouderFaculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.ORCID 0000-0003-3610-3899
Michal KucielPoison Information Centre, Department of Toxicology and Environmental Disease, Faculty of Medicine, Jagiellonian University, Kopernika 15, 30-501 Cracow, Poland.
Stelios KarapanagiotisFaculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.
Giacomo ZacconeDepartment of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168 Messina, Italy.
Jorge M O FernandesFaculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.ORCID 0000-0002-2550-1640
Nord University · NOUniversity of Messina · ITJagiellonian University · PLUniversidad de Cantabria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are proteins that contain highly conserved functional domains and sequence motifs that are correlated with their unique biophysical activities, to regulate cardiac pacemaker activity and synaptic transmission. These pacemaker proteins have been studied in mammalian species, but little is known now about their heart distribution in lower vertebrates and c-AMP modulation. Here, we characterized the pacemaker system in the heart of the wild Atlantic cod (

Indexed as

Ion Channel GatingAnimalsFish ProteinsGadus morhuaHeartHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMyocytes, CardiacProtein IsoformsSynaptic TransmissionFish ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsProtein IsoformsAtlantic codcardiac pacemakerhyperpolarization-activated cyclic nucleotide-gated (HCN) channelsinnervationintracardiac neurons

Identifiers

PMID34299159
PMCPMC8307021
OpenAlexW3180644084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.