Evidence map›Paper›PMID 34299132›Full record

ReviewInternational journal of molecular sciences2021

Cell Sources for Cultivated Meat: Applications and Considerations throughout the Production Workflow.

Jacob Reiss, Samantha Robertson, Masatoshi Suzuki

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Assessment of Bovine Collagen Manufactured via Cellular Agriculture.ACS biomaterials science & engineering · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Compression bioreactor for cultured meat.Current research in food science · 2026
    Article
  15. Review
  16. Bioprocess Engineering for Cultivated Meat.Advances in biochemical engineering/biotechnology · 2026
    Review
  17. Review
  18. Review
  19. Review
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob ReissDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Samantha RobertsonDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Masatoshi SuzukiDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3253-0711

Funding

Stem cell-based tissue engineering for myotendinous junction modeling and repairR01AR077191 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI SUZUKI, MASATOSHI · 2020 to 2024
$1.7M
Muscle stem cells: New ALS growth factor therapy and disease modelR01NS091540 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI SUZUKI, MASATOSHI · 2015 to 2019
$1.7M
NIAMS NIH HHS R01 AR077191NIAMS NIH HHS R01AR077191NINDS NIH HHS R01 NS091540NINDS NIH HHS R01NS091540The Good Food Institute N/AUW School of Veterinary Medicine N/AUW Stem Cell & Regenerative Medicine Center N/A
6 · The paper itself

Abstract

Cellular agriculture is an emerging scientific discipline that leverages the existing principles behind stem cell biology, tissue engineering, and animal sciences to create agricultural products from cells in vitro. Cultivated meat, also known as clean meat or cultured meat, is a prominent subfield of cellular agriculture that possesses promising potential to alleviate the negative externalities associated with conventional meat production by producing meat in vitro instead of from slaughter. A core consideration when producing cultivated meat is cell sourcing. Specifically, developing livestock cell sources that possess the necessary proliferative capacity and differentiation potential for cultivated meat production is a key technical component that must be optimized to enable scale-up for commercial production of cultivated meat. There are several possible approaches to develop cell sources for cultivated meat production, each possessing certain advantages and disadvantages. This review will discuss the current cell sources used for cultivated meat production and remaining challenges that need to be overcome to achieve scale-up of cultivated meat for commercial production. We will also discuss cell-focused considerations in other components of the cultivated meat production workflow, namely, culture medium composition, bioreactor expansion, and biomaterial tissue scaffolding.

Indexed as

AnimalsCell Culture TechniquesFood SupplyMeatSatellite Cells, Skeletal MuscleStem CellsTissue Engineeringcell sourcingcellular agriculturecultivated meatprimary cellsskeletal muscle tissue engineeringstem/progenitor cells

Identifiers

PMID34299132
PMCPMC8307620

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.