Evidence map›Paper›PMID 34299125›Full record

SynthesisInternational journal of molecular sciences2021

Biomarkers of Genotoxicity in Medical Workers Exposed to Low-Dose Ionizing Radiation: Systematic Review and Meta-Analyses.

Clémence Baudin, Marie-Odile Bernier, Dmitry Klokov, Maria Grazia Andreassi

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Genotoxicity of cancer therapies and the risk of secondary malignancies: toward personalized prevention.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Occupational Hazards in Cardiac Catheterization Laboratories: Radiation and Beyond-ANMCO Position Paper Update 2026.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  8. Review
  9. Article
  10. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Occupational exposures and age-related cataract: A review.Archives of environmental & occupational health · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Clémence BaudinIonizing Radiation Epidemiology Laboratory, Institute for Radiological Protection and Nuclear Safety, 92262 Fontenay-aux-Roses, France.
Marie-Odile BernierIonizing Radiation Epidemiology Laboratory, Institute for Radiological Protection and Nuclear Safety, 92262 Fontenay-aux-Roses, France.
Dmitry KlokovExperimental Radiotoxicology and Radiobiology Laboratory, Institute for Radiological Protection and Nuclear Safety, 92262 Fontenay-aux-Roses, France.ORCID 0000-0003-1629-1431
Maria Grazia AndreassiCNR Institute of Clinical Physiology, 56124 Pisa, Italy.
Istituto di Fisiologia Clinica · ITUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medical staff represent the largest group of workers occupationally exposed to ionizing radiation (IR). Chronic exposure to low-dose IR may result in DNA damage and genotoxicity associated with increased risk of cancer. This review aims to identify the genotoxicity biomarkers that are the most elevated in IR-exposed vs. unexposed health workers. A systematic review of the literature was performed to retrieve relevant studies with various biomarkers of genotoxicity. Subsequent meta-analyses produced a pooled effect size for several endpoints. The search procedure yielded 65 studies. Chromosome aberrations (CA) and micronuclei (MN) frequencies were significantly different between IR-exposed and unexposed workers (θ

Indexed as

DNA DamageRadiation, IonizingBiomarkersChromosome AberrationsDose-Response Relationship, RadiationHealth PersonnelHumansOccupational ExposureBiomarkerscytogenetic biomarkersDNA integrityionizing radiationmedical workersmeta-analysissystematic review

Identifiers

PMID34299125
PMCPMC8304237
OpenAlexW3178650853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.