Evidence map›Paper›PMID 34299087›Full record

ArticleInternational journal of molecular sciences2021

Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction.

Ciara N Murphy, Susan P Walker, Teresa M MacDonald, Emerson Keenan, Natalie J Hannan, Mary E Wlodek, Jenny Myers, Jessica F Briffa, Tania Romano, Alexandra Roddy Mitchell and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Placental Related Disorders of Pregnancy.International journal of molecular sciences · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Ciara N MurphyThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.ORCID 0000-0001-6996-7250
Susan P WalkerThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Teresa M MacDonaldThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.ORCID 0000-0001-9099-7745
Emerson KeenanThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-1966-2293
Natalie J HannanThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Mary E WlodekThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.ORCID 0000-0002-8490-9099
Jenny MyersManchester Academic Health Science Centre, St Mary's Hospital, University of Manchester, Manchester M13 OJH, UK.
Jessica F BriffaThe Department of Anatomy and Physiology, The University of Melbourne, VIC 3010, Australia.
Tania RomanoThe Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC 3086, Australia.ORCID 0000-0002-8581-2256
Alexandra Roddy MitchellThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Carole-Anne WhighamThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Ping CannonThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Tuong-Vi NguyenThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Manju KandelThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-1317-5232
Natasha PritchardThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.ORCID 0000-0002-7388-2193
Stephen TongThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
Tu'uhevaha J Kaitu'u-LinoThe Department of Obstetrics and Gynaecology, Mercy Hospital for Women, The University of Melbourne, Heidelberg, VIC 3084, Australia.
The University of Melbourne · AULa Trobe University · AUManchester Academic Health Science Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functionally related placental protease inhibitor. This study aimed to characterise SPINT2 expression in placental insufficiency. Circulating SPINT2 was assessed in three prospective cohorts, collected at the following: (1) term delivery (

Indexed as

AdolescentBiomarkersFemaleFetal Growth RetardationHumansInfant, NewbornInfant, Small for Gestational AgeLongitudinal StudiesMembrane GlycoproteinsPlacentaPlacenta DiseasesPre-EclampsiaPregnancyProspective StudiesTrophoblastsBiomarkersMembrane GlycoproteinsSPINT2 protein, humanfoetal growth restrictionintrauterine growth restrictionplacental insufficiencypreeclampsiasmall for gestational ageSPINT2/HAI-2

Identifiers

PMID34299087
PMCPMC8305184
OpenAlexW3180265541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.