Evidence map›Paper›PMID 34299083›Full record

ArticleInternational journal of molecular sciences2021

Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice.

Eileen Carry, Dushyant Kshatriya, Joshua Silva, Daryl L Davies, Bo Yuan, Qingli Wu, Harna Patel, Elizabeth R Park, John Gilleran, Lihong Hao and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Metabolic gene signature in white adipose tissue of oral doses raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] that prevent diet-induced weight gain and induce loss of righting reflex.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Article
  7. Review
  8. Article
  9. Phenolics as GABAMolecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Eileen CarryDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-1488-3567
Dushyant KshatriyaDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Joshua SilvaTitus Family Department of Clinical Pharmacy, School of Pharmacy, University Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-2010-729X
Daryl L DaviesTitus Family Department of Clinical Pharmacy, School of Pharmacy, University Southern California, Los Angeles, CA 90089, USA.
Bo YuanNew Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Qingli WuDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Harna PatelNew Use Agriculture & Natural Plant Products Program, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Elizabeth R ParkDepartment of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.
John GilleranDepartment of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.
Lihong HaoDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0001-7795-6981
Jacques RobergeDepartment of Molecular Design and Synthesis, Office of Research and Economic Development, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-7810-4139
Nicholas T BelloDepartment of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0001-5300-5604
James E SimonDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · USUniversity of Southern California · US

Funding

Regulation of Alcohol Intake by Purinergic P2X4 ReceptorsR01AA022448 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DAVIES, DARYL L · 2013 to 2020
$2.9M
New Jersey Agricultural Experiment Station NJ06280New Jersey Health Foundation NJ12170NIH HHS R01AA022448
6 · The paper itself

Abstract

Dihydromyricetin is a natural bioactive flavonoid with unique GABA

Indexed as

Alcoholic IntoxicationAnimalsBrainCentral Nervous System DepressantsEthanolFemaleFlavonolsMaleMiceMice, Inbred C57BLCentral Nervous System DepressantsdihydromyricetinEthanolFlavonolsacute alcohol intoxicationalcohol use disorderbioavailabilitydihydromyricetinGABAA receptorsloss of righting reflexmetabolism

Identifiers

PMID34299083
PMCPMC8307506
OpenAlexW3179773172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.