Evidence map›Paper›PMID 34299081›Full record

ReviewInternational journal of molecular sciences2021

Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants.

Mousa A Alghuthaymi, Aftab Ahmad, Zulqurnain Khan, Sultan Habibullah Khan, Farah K Ahmed, Sajid Faiz, Eugenie Nepovimova, Kamil Kuča, Kamel A Abd-Elsalam

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Review
  3. Nature Inspired Delivery Vehicles for CRISPR-Based Genome Editing.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Recent Advances in Tomato Gene Editing.International journal of molecular sciences · 2024
    Review
  10. How Advanced are Nanocarriers for Effective Subretinal Injection?International journal of nanomedicine · 2024
    Review
  11. Review
  12. Review
  13. Review
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  15. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Mousa A AlghuthaymiBiology Department, Science and Humanities College, Shaqra University, Alquwayiyah 19245, Saudi Arabia.
Aftab AhmadDepartment of Biochemistry, University of Agriculture, Faisalabad 38040, Pakistan.
Zulqurnain KhanInstitute of Plant Breeding and Biotechnology, MNS University of Agriculture, Multan 60000, Pakistan.ORCID 0000-0002-6910-7389
Sultan Habibullah KhanCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38040, Pakistan.
Farah K AhmedBiotechnology English Program, Faculty of Agriculture, Cairo University, Giza 12613, Egypt.ORCID 0000-0002-9756-2661
Sajid FaizDepartment of Plant Breeding and Genetics, University of Haripur, Haripur 22620, Pakistan.ORCID 0000-0001-9097-4359
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
Kamil KučaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Kamel A Abd-ElsalamAgricultural Research Center (ARC), Plant Pathology Research Institute, 9-Gamaa St., Giza 12619, Egypt.ORCID 0000-0002-4042-4022
University of Agriculture Faisalabad · PKUniversity of Hradec Králové · CZAgricultural Research Center · EGCairo University · EGMuhammad Nawaz Shareef University of Agriculture · PKShaqra University · SAUniversity of Haripur · PK

Funding

Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic UHK project VT2019-2021
6 · The paper itself

Abstract

Rapid developments in the field of plant genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems necessitate more detailed consideration of the delivery of the CRISPR system into plants. Successful and safe editing of plant genomes is partly based on efficient delivery of the CRISPR system. Along with the use of plasmids and viral vectors as cargo material for genome editing, non-viral vectors have also been considered for delivery purposes. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, and protein- and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have a decreased immune response, an advantage over viral vectors, and offer additional flexibility in their design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. This review is dedicated to describing the delivery methods of CRISPR system into plants with emphasis on the use of non-viral vectors.

Indexed as

CRISPR-Cas SystemsGene EditingGenetic TherapyExosomesGenome, PlantLiposomesNanoparticlesPlantsLiposomesCRISPRexosomes and liposomesgenome editingnanoparticles

Identifiers

PMID34299081
PMCPMC8304373
OpenAlexW3182877332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.