ArticleInternational journal of molecular sciences2021
Antimelanogenesis Effects of Theasinensin A.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Postbiotic Effects ofMicroorganisms · 2025Article
- Effects of pine needle essential oil on melanin synthesis in B16F10 cells and its mechanism.Biomedical reports · 2025Article
- Drug Repurposing of Voglibose, a Diabetes Medication for Skin Health.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Green Tea Catechins and Skin Health.Antioxidants (Basel, Switzerland) · 2024Review
- Correlation analysis of secondary metabolites and disease resistance activity of different varieties of Congou black tea based on LC-MS/MS and TCMSP.Food chemistry: X · 2024Article
- Exploration of Compounds with 2-Phenylbenzo[Molecules (Basel, Switzerland) · 2024Article
- Phenolic acids inJournal of ginseng research · 2023Article
- EGCG, GCG, TFDG, or TSA Inhibiting Melanin Synthesis by Downregulating MC1R Expression.International journal of molecular sciences · 2023Article
- Pueraria protein extract inhibits melanogenesis and promotes melanoma cell apoptosis through the regulation of MITF and mitochondrial‑related pathways.Molecular medicine reports · 2023Article
- Anti-Melanogenesis Effects of a Cyclic Peptide Derived from Flaxseed via Inhibition of CREB Pathway.International journal of molecular sciences · 2022Article
- SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells.International journal of molecular sciences · 2022Article
- Protective Function ofPlants (Basel, Switzerland) · 2022Article
- In Vitro Anti-Photoaging and Skin Protective Effects ofPlants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Theasinensin A (TSA) is a major group of catechin dimers mainly found in oolong tea and black tea. This compound is also manufactured with epigallocatechin gallate (EGCG) as a substrate and is refined after the enzyme reaction. In previous studies, TSA has been reported to be effective against inflammation. However, the effect of these substances on skin melanin formation remains unknown. In this study, we unraveled the role of TSA in melanogenesis using mouse melanoma B16F10 cells and normal human epidermal melanocytes (NHEMs) through reverse transcription polymerase chain reaction (RT-PCR), Western blotting analysis, luciferase reporter assay, and enzyme-linked immunosorbent assay analysis. TSA inhibited melanin formation and secretion in α-melanocyte stimulating hormone (α-MSH)-induced B16F10 cells and NHEMs. TSA down-regulated the mRNA expression of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.