ArticleInternational journal of molecular sciences2021
Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Advances and challenges in the mechanistic understanding of beta-cell dysfunction in gestational diabetes mellitus.Journal of animal science · 2026Review
- Association of Maternal Hyperlipidemia Combined with Gestational Diabetes Mellitus with Adverse Maternal and Neonatal Outcomes: A Retrospective Cohort Study.International journal of women's health · 2026Article
- Article
- Cardiovascular outcome in 12-month-old male and female offspring of metformin-treated obese mice.The Journal of physiology · 2025Article
- When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity.International journal of molecular sciences · 2025Review
- Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans.Open biology · 2025Article
- Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding.Journal of diabetes investigation · 2025Article
- ZJU index as a predictive biomarker of gestational diabetes mellitus: a prospective cohort analysis.Frontiers in nutrition · 2025Article
- Evaluating the Impact of Maternal Lipid Profiles on Fetal Cardiac Function at Mid-Gestation: An Observational Study.Clinics and practice · 2024Article
- Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data.Diabetology & metabolic syndrome · 2024Article
- Systemic analysis of lipid metabolism from individuals to multi-organism systems.Molecular omics · 2024Article
- Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice.PloS one · 2024Article
- The dynamic inflammatory profile of pregnancy can be monitored using a novel lipid-based mass spectrometry technique.Molecular omics · 2023Article
- Gestational Vitamin E Status and Gestational Diabetes Mellitus: A Retrospective Cohort Study.Nutrients · 2023Article
- Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study.BMC medicine · 2023Article
- Placental Malfunction, Fetal Survival and Development Caused by Sow Metabolic Disorder: The Impact of Maternal Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
- Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice.International journal of molecular sciences · 2023Article
- Gestational Diabetes Mellitus and Antenatal Corticosteroid Therapy-A Narrative Review of Fetal and Neonatal Outcomes.Journal of clinical medicine · 2022Review
- Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring.Diabetologia · 2022Article
- Lipid metabolism is dysregulated in a mouse model of diabetes.Metabolomics : Official journal of the Metabolomic Society · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. Our results suggest that the start of pregnancy is associated with several changes in lipid metabolism, including fewer variables associated with de novo lipogenesis and fewer PUFA-containing lipids in the circulation. Several of the changes in lipid metabolism in healthy pregnancies were less apparent or occurred later in dams who developed GDM. Some changes in maternal lipid metabolism in the obese-GDM group were so late as to only occur as the control dams' systems began to switch back towards the non-pregnant state. These results demonstrate that lipid metabolism is modulated in healthy pregnancy and the timing of these changes is altered in GDM pregnancies. These findings raise important questions about how lipid metabolism contributes to changes in metabolism during healthy pregnancies. Furthermore, as alterations in the lipidome are present before the loss of glucose tolerance, they could contribute to the development of GDM mechanistically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.