ReviewInternational journal of molecular sciences2021
Factors Influencing the Antibacterial Activity of Chitosan and Chitosan Modified by Functionalization.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 1 synthesis or guideline pooled it, 515 citations in OpenAlex.
- Exploring the role of density functional theory in the design of gold nanoparticles for targeted drug delivery: a systematic review.Journal of molecular modeling · 2025Pooled it
- Chitosan-Based Active Films Enriched with Thyme Essential Oil for Extending the Shelf Life of Refrigerated Chicken Meat.Foods (Basel, Switzerland) · 2026Article
- Antibiotic-Free Strategies for Managing Antimicrobial-Resistant Infections.Pharmaceutics · 2026Review
- Multifunctional Janus Membrane Promotes Neurovascular Network Regeneration for Diabetic Wound Healing.Advanced healthcare materials · 2026Article
- Toward Precision in Biomarker Analysis: A Novel Malondialdehyde Detection Method Based on Molecularly Imprinted Polymers.ACS omega · 2026Article
- Green synthesis of silver titanium dioxide nanocomposites functionalized with chitosan for enhanced antimicrobial and antioxidant activity.Discover nano · 2026Article
- Valorization of Corn Steep Liquor and Glycerol for Fungal Chitosan Production by Mucorales from Brazilian Biomes: Structural Characterization and Antimicrobial Activity.Molecules (Basel, Switzerland) · 2026Article
- Stress, mood, and Parkinson's disease: selective dysregulation of corticotropin-releasing hormone and urocortin neurocircuits.GeroScience · 2026Article
- Article
- Optimization of Chitosan/Modified Chitosan-Silver(I) Composite Film and Application to Strawberries.Foods (Basel, Switzerland) · 2026Article
- Article
- Recent advances in chitosan-based nanomaterials for enhanced antimicrobial activity.World journal of microbiology & biotechnology · 2026Review
- A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway.Bioactive materials · 2026Article
- Chitosan-based nanozyme hydrogels: Advanced antioxidant and sustained-release systems for the prevention and treatment of skin photoaging.International journal of pharmaceutics: X · 2026Review
- Review
- Nanochitosan-based adsorbents for sustainable treatment of palm oil mill effluent.RSC advances · 2026Review
- A dual crosslinked biodegradable zwitterionic chitosan-lignosulfonate derived aerogel for microbial decontamination of wastewater.RSC advances · 2026Article
- Synthesis and biological study of thiopheneyl/piperazinl-α-aminophosphonate-chitosan conjugates as biologically active carriers for controlled delivery of curcumin.Scientific reports · 2026Article
- An intelligent nano-engineered PLGA@IGF-1 hydrogel for programmed immune modulation and tendon regeneration via IGF-1R/AKT signaling.Journal of nanobiotechnology · 2026Article
- Hydrogel and Injectable Platelet-Rich Fibrin: A Synergistic Approach to Osteogenesis.European journal of dentistry · 2026Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biomedical and therapeutic importance of chitosan and chitosan derivatives is the subject of interdisciplinary research. In this analysis, we intended to consolidate some of the recent discoveries regarding the potential of chitosan and its derivatives to be used for biomedical and other purposes. Why chitosan? Because chitosan is a natural biopolymer that can be obtained from one of the most abundant polysaccharides in nature, which is chitin. Compared to other biopolymers, chitosan presents some advantages, such as accessibility, biocompatibility, biodegradability, and no toxicity, expressing significant antibacterial potential. In addition, through chemical processes, a high number of chitosan derivatives can be obtained with many possibilities for use. The presence of several types of functional groups in the structure of the polymer and the fact that it has cationic properties are determinant for the increased reactive properties of chitosan. We analyzed the intrinsic properties of chitosan in relation to its source: the molecular mass, the degree of deacetylation, and polymerization. We also studied the most important extrinsic factors responsible for different properties of chitosan, such as the type of bacteria on which chitosan is active. In addition, some chitosan derivatives obtained by functionalization and some complexes formed by chitosan with various metallic ions were studied. The present research can be extended in order to analyze many other factors than those mentioned. Further in this paper were discussed the most important factors that influence the antibacterial effect of chitosan and its derivatives. The aim was to demonstrate that the bactericidal effect of chitosan depends on a number of very complex factors, their knowledge being essential to explain the role of each of them for the bactericidal activity of this biopolymer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.