Evidence map›Paper›PMID 34299041›Full record

ArticleInternational journal of molecular sciences2021

A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η

Alice De Palo, Dijana Draca, Maria Grazia Murrali, Stefano Zacchini, Guido Pampaloni, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Fabio Marchetti

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Cytotoxic Organometallic Iridium(III) Complexes.Molecules (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alice De PaloDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, I-56124 Pisa, Italy.
Dijana DracaDepartment of Immunology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.ORCID 0000-0001-8226-1623
Maria Grazia MurraliDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, I-56124 Pisa, Italy.
Stefano ZacchiniDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Viale Risorgimento 4, I-40136 Bologna, Italy.ORCID 0000-0003-0739-0518
Guido PampaloniDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, I-56124 Pisa, Italy.
Sanja MijatovicDepartment of Immunology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Danijela Maksimovic-IvanicDepartment of Immunology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia.
Fabio MarchettiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, I-56124 Pisa, Italy.ORCID 0000-0002-3683-8708
University of Pisa · ITUniversity of Belgrade · RSUniversity of Bologna · IT

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-9/2021-14/200007Università di Pisa PRA_2020_39
6 · The paper itself

Abstract

Piano-stool iridium complexes based on the pentamethylcyclopentadienyl ligand (Cp*) have been intensively investigated as anticancer drug candidates and hold much promise in this setting. A systematic study aimed at outlining the effect of Cp* mono-derivatization on the antiproliferative activity is presented here. Thus, the dinuclear complexes [Ir(η

Indexed as

AnimalsAntineoplastic AgentsApoptosisCell ProliferationCoordination ComplexesHumansIridiumLigandsMiceModels, MolecularNeoplasmsRatsStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsCoordination ComplexesIridiumLigandsapoptosisbioorganometallic chemistrycell proliferationcytotoxicityorganoiridium complexessenescence

Identifiers

PMID34299041
PMCPMC8306930
OpenAlexW3182112526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.